Improved survival using an intensive, pediatric-based chemotherapy regimen in adults with T-cell acute lymphoblastic leukemia

被引：17

作者：

Al-Khabori, Murtadha ^{[1
]}

Minden, Mark D. ^{[1
]}

Yee, Karen W. L. ^{[1
]}

Gupta, Vikas ^{[1
]}

Schimmer, Aaron D. ^{[1
]}

Schuh, Andre C. ^{[1
]}

Xu, Wei ^{[2
]}

Brandwein, Joseph M. ^{[1
]}

机构：

[1] Univ Toronto, Princess Margaret Hosp, Dept Med Oncol & Hematol, Toronto, ON M5G 2M9, Canada

[2] Univ Toronto, Princess Margaret Hosp, Dept Biostat, Toronto, ON M5G 2M9, Canada

来源：

LEUKEMIA & LYMPHOMA | 2010年 / 51卷 / 01期

关键词：

Acute lymphoblastic leukemia; chemotherapeutic approaches; prognostication; COMPLETE REMISSION; INDUCTION; CHILDREN; TRIAL; ADOLESCENTS; THERAPY;

D O I：

10.3109/10428190903388376

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

All patients with newly diagnosed T-cell acute lymphoblastic leukemia (T-ALL) and treated over a 17-year period at a single institution were retrospectively analyzed. From 1990 to 2000, 40 patients were treated with a variety of adult-based ALL regimens. From 2000 to 2007, a pediatric-based protocol, DFCI (Dana Farber Cancer Institute), was used as the standard regimen for all patients (n = 32). The two groups (DFCI and non-DFCI) had comparable baseline characteristics. Complete response rates were not significantly different between the DFCI- and non-DFCI-treated groups. The 3-year relapse free survival (RFS) and overall survival (OS) were significantly higher in the DFCI-treated group (p < 0.0001 and p = 0.0003, respectively). On multivariate analysis, the treatment group (DFCI vs. non-DFCI) was the major prognostic factor influencing both RFS and OS. The results provide evidence supporting the superior efficacy of asparaginase-intensive pediatric-based regimens for adults with T-ALL.

引用

页码：61 / 65

页数：5

共 14 条

[1] Adult precursor T-lymphoblastic leukemia/lymphoma with myeloid-associated antigen expression is associated with a lower complete remission rate following induction chemotherapy [J].

Al Khabori, Murtadha ;

Samiee, Samira ;

Fung, Sharon ;

Xu, Wei ;

Brandwein, Joseph ;

Patterson, Bruce ;

Brien, William ;

Chang, Hong .

ACTA HAEMATOLOGICA, 2008, 120 (01) :5-10

[2] Favorable outcome for adolescents with acute lymphoblastic leukemia treated on Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium Protocols [J].

Barry, Elly ;

DeAngelo, Daniel J. ;

Neuberg, Donna ;

Stevenson, Kristen ;

Loh, Mignon L. ;

Asselin, Barbara L. ;

Barr, Ronald D. ;

Clavell, Luis A. ;

Hurwitz, Craig A. ;

Moghrabi, Albert ;

Samson, Yvan ;

Schorin, Marshall ;

Cohen, Harvey J. ;

Sallan, Stephen E. ;

Silverman, Lewis B. .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (07) :813-819

[3] Should adolescents with acute lymphoblastic leukemia be treated as old children or young adults?: Comparison of the French FRALLE-93 and LALA-94 trials [J].

Boissel, N ;

Auclerc, MF ;

Lhéritier, V ;

Perel, Y ;

Thomas, X ;

Leblanc, T ;

Rousselot, P ;

Cayuela, JM ;

Gabert, J ;

Fegueux, N ;

Piguet, C ;

Huguet-Rigal, F ;

Berthou, C ;

Boiron, JM ;

Poutos, C ;

Michel, G ;

Fière, D ;

Leverger, G ;

Dombret, H ;

Baruchel, A .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (05) :774-780

[4]

BOUCHEIX C, 1994, BLOOD, V84, P1603

[5] Diagnostic cerebrospinal fluid examination in children with acute lymphoblastic leukemia:: Significance of low leukocyte counts with blasts or traumatic lumbar puncture [J].

Bürger, B ;

Zimmermann, M ;

Mann, G ;

Kühl, J ;

Löning, L ;

Reihm, H ;

Reiter, A ;

Schrappe, M .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (02) :184-188

[6] Leukocyte count as a predictor of death during remission induction in acute myeloid leukemia [J].

Greenwood, M. J. ;

Seftel, M. D. ;

Richardson, C. ;

Barbaric, D. ;

Barnett, M. J. ;

Bruyere, H. ;

Forrest, D. L. ;

Horsman, D. E. ;

Smith, C. ;

Song, K. ;

Sutherland, H. J. ;

Toze, C. L. ;

Nevill, T. J. ;

Nantel, S. H. ;

Hogge, D. E. .

LEUKEMIA & LYMPHOMA, 2006, 47 (07) :1245-1252

[7] The role of allogeneic bone marrow transplantation in adult patients below the age of 55 years with acute lymphoblastic leukemia in first complete remission:: a donor vs no donor comparison [J].

Gupta, V ;

Yi, QL ;

Brandwein, J ;

Minden, MD ;

Schuh, AC ;

Wells, RA ;

Chun, K ;

Kamel-Reid, S ;

Tsang, R ;

Daly, A ;

Kiss, T ;

Lipton, JH ;

Messner, HA .

BONE MARROW TRANSPLANTATION, 2004, 33 (04) :397-404

[8] Pediatric-Inspired Therapy in Adults With Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: The GRAALL-2003 Study [J].

Huguet, Francoise ;

Leguay, Thibaut ;

Raffoux, Emmanuel ;

Thomas, Xavier ;

Beldjord, Kheira ;

Delabesse, Eric ;

Chevallier, Patrice ;

Buzyn, Agnes ;

Delannoy, Andre ;

Chalandon, Yves ;

Vernant, Jean-Paul ;

Lafage-Pochitaloff, Marina ;

Chassevent, Agnes ;

Lheritier, Veronique ;

Macintyre, Elizabeth ;

Bene, Marie-Christine ;

Ifrah, Norbert ;

Dombret, Herve .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (06) :911-918

[9] Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia [J].

Kantarjian, H ;

Thomas, D ;

O'Brien, S ;

Cortes, J ;

Giles, F ;

Jeha, S ;

Bueso-Ramos, CE ;

Pierce, S ;

Shan, JQ ;

Koller, C ;

Beran, M ;

Keating, M ;

Freireich, EJ .

CANCER, 2004, 101 (12) :2788-2801

[10] Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: results from the international ALL trial MRC UKALL XII/ECOG E2993 [J].

Lazarus, Hillard M. ;

Richards, Susan M. ;

Chopra, Raj ;

Litzow, Mark R. ;

Burnett, Alan K. ;

Wiernik, Peter H. ;

Franklin, Ian M. ;

Tallman, Martin S. ;

Cook, Lucy ;

Buck, Georgina ;

Durrant, I. Jill ;

Rowe, Jacob M. ;

Goldstone, Anthony H. ;

Grp, Eastern Cooperative Oncology .

BLOOD, 2006, 108 (02) :465-472

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