Magnetic resonance imaging tumor regression shrinkage patterns after neoadjuvant chemotherapy in patients with locally advanced breast cancer: Correlation with tumor biological subtypes and pathological response after therapy
Tumor biological subtypes;
breast magnetic resonance imaging;
neoadjuvant chemotherapy;
shrinkage pattern;
tumor regression;
GRADING SYSTEM;
ACCURACY;
MRI;
ANGIOGENESIS;
D O I:
10.1177/1010428317694540
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
The objective of this study is to analyze magnetic resonance imaging shrinkage pattern of tumor regression after neoadjuvant chemotherapy and to evaluate its relationship with biological subtypes and pathological response. We reviewed the magnetic resonance imaging studies of 51 patients with single mass-enhancing lesions (performed at time 0 and at the II and last cycles of neoadjuvant chemotherapy). Tumors were classified as Luminal A, Luminal B, HER2+, and Triple Negative based on biological and immunohistochemical analysis after core needle biopsy. We classified shrinkage pattern, based on tumor regression morphology on magnetic resonance imaging at the II cycle, as concentric, nodular, and mixed. We assigned a numeric score (0: none; 1: low; 2: medium; 3: high) to the enhancement intensity decrease. Pathological response on the surgical specimen was classified as complete (grade 5), partial (grades 4-3), and non- response (grades 1-2) according to Miller and Payne system. Fisher test was used to relate shrinkage pattern with biological subtypes and final pathological response. Seventeen patients achieved complete response, 25 partial response, and 9 non-response. A total of 13 lesions showed nodular pattern, 20 concentric, and 18 mixed. We found an association between concentric pattern and HER2+ (p < 0.001) and mixed pattern and Luminal A lesions (p < 0.001). We observed a statistical significant correlation between concentric pattern and complete response (p < 0.001) and between mixed pattern and non-response (p = 0.005). Enhancement intensity decrease 3 was associated with complete response (p < 0.001). Shrinkage pattern and enhancement intensity decrease may serve as early response indicators after neoadjuvant chemotherapy. Shrinkage pattern correlates with tumor biological subtypes.
机构:
Univ Tubingen, Dept Gynaecol, Tubingen, Germany
Brustzentrum Kantonsspital St Gallen, St Gallen, SwitzerlandGerman Breast Grp, D-63263 Neu Isenburg, Germany
Huober, Jens
;
von Minckwitz, Gunter
论文数: 0引用数: 0
h-index: 0
机构:
German Breast Grp, D-63263 Neu Isenburg, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
von Minckwitz, Gunter
;
Denkert, Carsten
论文数: 0引用数: 0
h-index: 0
机构:
Charite, Inst Pathol, Translat Tumorpathol Unit, Berlin, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Denkert, Carsten
;
Tesch, Hans
论文数: 0引用数: 0
h-index: 0
机构:
Bethanien Krankenhaus, Frankfurt, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Tesch, Hans
;
Weiss, Erich
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Sindelfingen Boblingen, Boblingen, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Weiss, Erich
;
Zahm, Dirk Michael
论文数: 0引用数: 0
h-index: 0
机构:
SRH Waldkliniken, Gera, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Zahm, Dirk Michael
;
Belau, Antje
论文数: 0引用数: 0
h-index: 0
机构:
Ernst Moritz Arndt Univ Greifswald, Dept Gynaecol, Greifswald, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Belau, Antje
;
Khandan, Fariba
论文数: 0引用数: 0
h-index: 0
机构:
St Markus Hosp, Frankfurt, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Khandan, Fariba
;
Hauschild, Maik
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Rheinfelden, Rheinfelden, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Hauschild, Maik
;
Thomssen, Christoph
论文数: 0引用数: 0
h-index: 0
机构:
Univ Halle Wittenberg, Dept Gynaecol, Halle, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Thomssen, Christoph
;
Hoegel, Bernhard
论文数: 0引用数: 0
h-index: 0
机构:
Frauenklin Roten Kreuz, Munich, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Hoegel, Bernhard
;
Darb-Esfahani, Silvia
论文数: 0引用数: 0
h-index: 0
机构:
Charite, Inst Pathol, Translat Tumorpathol Unit, Berlin, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Darb-Esfahani, Silvia
;
Mehta, Keyur
论文数: 0引用数: 0
h-index: 0
机构:
German Breast Grp, D-63263 Neu Isenburg, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Mehta, Keyur
;
Loibl, Sibylle
论文数: 0引用数: 0
h-index: 0
机构:
German Breast Grp, D-63263 Neu Isenburg, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
机构:
Natl Canc Ctr, Ctr Clin Trials, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Jeong, Jae-Heon
;
Jung, So-Youn
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Jung, So-Youn
;
Park, In Hae
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Park, In Hae
;
Lee, Keun Seok
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Lee, Keun Seok
;
Kang, Han-Sung
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Kang, Han-Sung
;
Kim, Seok Won
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Kim, Seok Won
;
Kwon, Youngmee
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Kwon, Youngmee
;
Kim, Eun A.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Kim, Eun A.
;
Ko, Kyung Lan
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Ko, Kyung Lan
;
Nam, Byung-Ho
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Clin Trials, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Nam, Byung-Ho
;
Lee, Seeyoun
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Lee, Seeyoun
;
Ro, Jungsil
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Natl Canc Ctr, Ctr Clin Trials, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
机构:
Univ Tubingen, Dept Gynaecol, Tubingen, Germany
Brustzentrum Kantonsspital St Gallen, St Gallen, SwitzerlandGerman Breast Grp, D-63263 Neu Isenburg, Germany
Huober, Jens
;
von Minckwitz, Gunter
论文数: 0引用数: 0
h-index: 0
机构:
German Breast Grp, D-63263 Neu Isenburg, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
von Minckwitz, Gunter
;
Denkert, Carsten
论文数: 0引用数: 0
h-index: 0
机构:
Charite, Inst Pathol, Translat Tumorpathol Unit, Berlin, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Denkert, Carsten
;
Tesch, Hans
论文数: 0引用数: 0
h-index: 0
机构:
Bethanien Krankenhaus, Frankfurt, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Tesch, Hans
;
Weiss, Erich
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Sindelfingen Boblingen, Boblingen, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Weiss, Erich
;
Zahm, Dirk Michael
论文数: 0引用数: 0
h-index: 0
机构:
SRH Waldkliniken, Gera, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Zahm, Dirk Michael
;
Belau, Antje
论文数: 0引用数: 0
h-index: 0
机构:
Ernst Moritz Arndt Univ Greifswald, Dept Gynaecol, Greifswald, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Belau, Antje
;
Khandan, Fariba
论文数: 0引用数: 0
h-index: 0
机构:
St Markus Hosp, Frankfurt, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Khandan, Fariba
;
Hauschild, Maik
论文数: 0引用数: 0
h-index: 0
机构:
Hosp Rheinfelden, Rheinfelden, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Hauschild, Maik
;
Thomssen, Christoph
论文数: 0引用数: 0
h-index: 0
机构:
Univ Halle Wittenberg, Dept Gynaecol, Halle, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Thomssen, Christoph
;
Hoegel, Bernhard
论文数: 0引用数: 0
h-index: 0
机构:
Frauenklin Roten Kreuz, Munich, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Hoegel, Bernhard
;
Darb-Esfahani, Silvia
论文数: 0引用数: 0
h-index: 0
机构:
Charite, Inst Pathol, Translat Tumorpathol Unit, Berlin, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Darb-Esfahani, Silvia
;
Mehta, Keyur
论文数: 0引用数: 0
h-index: 0
机构:
German Breast Grp, D-63263 Neu Isenburg, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
Mehta, Keyur
;
Loibl, Sibylle
论文数: 0引用数: 0
h-index: 0
机构:
German Breast Grp, D-63263 Neu Isenburg, GermanyGerman Breast Grp, D-63263 Neu Isenburg, Germany
机构:
Natl Canc Ctr, Ctr Clin Trials, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Jeong, Jae-Heon
;
Jung, So-Youn
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Jung, So-Youn
;
Park, In Hae
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Park, In Hae
;
Lee, Keun Seok
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Lee, Keun Seok
;
Kang, Han-Sung
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Kang, Han-Sung
;
Kim, Seok Won
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Kim, Seok Won
;
Kwon, Youngmee
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Kwon, Youngmee
;
Kim, Eun A.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Kim, Eun A.
;
Ko, Kyung Lan
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Ko, Kyung Lan
;
Nam, Byung-Ho
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Clin Trials, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Nam, Byung-Ho
;
Lee, Seeyoun
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Lee, Seeyoun
;
Ro, Jungsil
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea
Natl Canc Ctr, Ctr Clin Trials, Goyang Si 410769, Gyeonggi Do, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang Si 410769, Gyeonggi Do, South Korea