Adjuvant radiotherapy and radioiodine treatment for locally advanced differentiated thyroid cancer: systematic review and meta-analysis

被引:3
|
作者
Dicuonzo, Samantha [1 ]
Pedretti, Sara [2 ]
Mangoni, Monica [3 ]
Monari, Fabio [4 ]
Fanetti, Giuseppe [5 ]
Borsatti, Eugenio [6 ]
Lombardi, Davide [7 ]
Vianello, Federica [8 ]
Iacobone, Maurizio [9 ]
Corvo, Renzo [10 ,11 ]
Magrini, Stefano M. [12 ]
Pappagallo, Giovanni [13 ]
Arcangeli, Stefano [14 ,15 ]
D'Angelillo, Rolando M. [16 ]
机构
[1] European Inst Oncol IRCCS, Dept Radiat Oncol, Milan, Italy
[2] ASST Spedali Civili, Dept Radiat Oncol, Brescia, Italy
[3] Univ Florence, Radiotherapy Unit, Dept Biomed Expt & Clin Sci, Florence, Italy
[4] Policlin S Orsola Malpighi IRCCS AOSP, Dept Radiat Oncol, Bologna, Italy
[5] Ctr Riferimento Oncol Aviano CRO IRCCS, Dept Radiat Oncol, Aviano, Italy
[6] Ctr Riferimento Oncol Aviano CRO IRCCS, Div Nucl Med, Aviano, Italy
[7] Univ Brescia, Dept Otorhinolaryngol Head & Neck Surg, Brescia, Italy
[8] IRCCS, Veneto Inst Oncol, Dept Radiat Oncol, Padua, Italy
[9] Univ Padua, Endocrine Surg Unit, Dept Surg Oncol & Gastroenterol, Padua, Italy
[10] Univ Genoa, Dept Radiat Oncol, Genoa, Italy
[11] IRCCS Osped Policlin San Martino, Genoa, Italy
[12] Univ Brescia, Dept Radiat Oncol, Brescia, Italy
[13] Mirano Hosp, Dept Med Oncol, Mirano, Italy
[14] ASST Monza, Dept Radiat Oncol, Milan, Italy
[15] Univ Milano Bicocca, Milan, Italy
[16] Univ Roma Tor Vergata, Radiat Oncol, Dept Biomed & Prevent, Rome, Italy
来源
TUMORI JOURNAL | 2021年 / 107卷 / 06期
关键词
Thyroid cancer; radiotherapy; radioiodine; GRADE recommendation; EXTERNAL-BEAM RADIOTHERAPY; SALIVARY-GLAND DYSFUNCTION; RADIOACTIVE IODINE; CARCINOMA; QUALITY; THERAPY; GRADE; GUIDELINES; MANAGEMENT; CONSENSUS;
D O I
10.1177/0300891621996817
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Treatment for locally advanced differentiated thyroid cancer is surgery followed by radioiodine while the role of adjuvant external beam radiotherapy (EBRT) is debated. Methods: The panel of the Italian Association of Radiotherapy and Clinical Oncology developed a clinical recommendation on the addition of EBRT to radioiodine after surgery for locally advanced differentiated thyroid cancer by using the Grades of Recommendation, Assessment, Development, and Evaluation methodology and the Evidence to Decision framework. A systematic review with meta-analysis about this topic was conducted with a focus on outcome of benefits and toxicity. Results: Locoregional control was improved by EBRT while no considerable toxicity impact was reported. Conclusion: The panel judged uncertain the benefit/harms balance; final recommendation was conditional both for EBRT + radioiodine and radioiodine alone in the adjuvant setting.
引用
收藏
页码:489 / 497
页数:9
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