Chorioangiomas - new insights into a well-known problem II. An immuno-histochemical investigation of 136 cases

被引:39
作者
Guschmann, M
Henrich, W
Dudenhausen, JW
机构
[1] Humboldt Univ, Charite, Fak Med, Inst Pathol,Abt Paidopathol & Placentol, D-13353 Berlin, Germany
[2] Humboldt Univ, Charite, Fak Med, Dept Obstet, D-13353 Berlin, Germany
关键词
angiogenesis; angiopoietin; chorioangioma; growth factor; PDGF;
D O I
10.1515/JPM.2003.023
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Aims. Chorioangiomas are benign tumors of the hemochorial placenta. They are malformations or hamartomas, formed as a result of defective angiogenesis. They are of clinical importance due to their association with premature placental release and pre-eclampsia. Methods. Since a link has been established in neoplasias between tumor growth and an increased expression of angiogenic growth factors, 136 samples of chorioangiornas and 136 samples of tumor-free placental tissue were examined in terms of proliferation rate and expression of the growth factors angiopoietin-1 and -2, the angiopoietin-receptorTie-2, PDGF and the PDFG beta-receptor. Results. The chorioangiomas exhibited differing proliferation rates, whereas tumor-free placental tissue barely proliferated at all. Angiopoietin expression was - morphologically - considerably higher within the chorioangiomas than in the comparison placentas; morphological amounts of the Tie-2 receptor were identical in all samples. Expression of PDGF and its receptor was the same for chorioangiomas and tumor-free placentas. Conclusions. According to this study and the current literature in the field of hamartomas and some neoplasia, we can assume that increased growth factor expression plays a role in the formation of chorioangiomas, since it stimulates proliferation in a wide variety of cell compartments.
引用
收藏
页码:170 / 175
页数:6
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