Central blood pressure relatesmore strongly to retinal arteriolar narrowing than brachial blood pressure: the Nagahama Study

被引:24
作者
Kumagai, Kyoko [1 ]
Tabara, Yasuharu [2 ]
Yamashiro, Kenji [1 ]
Miyake, Masahiro [1 ]
Akagi-Kurashige, Yumiko [1 ]
Oishi, Maho [1 ]
Yoshikawa, Munemitsu [1 ]
Kimura, Yugo [1 ]
Tsujikawa, Akitaka [1 ]
Takahashi, Yoshimitsu [3 ]
Setoh, Kazuya [2 ]
Kawaguchi, Takahisa [2 ]
Terao, Chikashi [2 ]
Yamada, Ryo [2 ]
Kosugi, Shinji [4 ]
Sekine, Akihiro [5 ]
Nakayama, Takeo [3 ]
Matsuda, Fumihiko [2 ]
Yoshimura, Nagahisa [1 ]
机构
[1] Kyoto Univ, Grad Sch Med, Dept Ophthalmol & Visual Sci, Kyoto 6068507, Japan
[2] Kyoto Univ, Grad Sch Med, Ctr Genom Med, Kyoto 6068507, Japan
[3] Kyoto Univ, Dept Hlth Informat, Sch Publ Hlth, Kyoto 6068507, Japan
[4] Kyoto Univ, Dept Med Eth & Med Genet, Sch Publ Hlth, Kyoto 6068507, Japan
[5] Kyoto Univ, Med Res Support Ctr, Kyoto 6068507, Japan
关键词
central blood pressure; retinal vessel caliber; small artery narrowing; CARDIOVASCULAR RISK-FACTORS; CENTRAL PULSE PRESSURE; VESSEL DIAMETERS; MICROVASCULAR ABNORMALITIES; VASCULAR CALIBER; ASIAN POPULATION; DISEASE; STROKE; INFLAMMATION; VALIDATION;
D O I
10.1097/HJH.0000000000000391
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Objectives: Although central blood pressure (BP) is considered to be more closely associated with large arterial remodeling and cardiovascular outcomes than brachial BP, few studies have investigated these associations with changes in small arteries. As morphological changes in retinal vessels might be associated with cardiovascular outcomes, we conducted a cross-sectional study to investigate the association of central BP with retinal vessel caliber. Methods: The study included 8054 Japanese participants. Central BP was estimated by the radial arterial waveform by calibrating brachial BP. Central retinal arteriolar equivalent (CRAE) was computationally measured using fundus photography. Results: CRAE was most strongly associated with central SBP (r = -0.324, P < 0.001), followed by DBP (r = -0.292, P < 0.001) and central pulse pressure (PP; r = -0.226, P < 0.001). The correlation coefficient between SBP and CRAE was significantly greater in central SBP than in brachial SBP (r = -0.300, P < 0.001). After adjustment for possible covariates, brachial SBP (beta = -0.221, P < 0.001) and central SBP (beta = -0.239, P < 0.001) were independently associated with CRAE. Further, higher brachial SBP (beta = -0.226, P < 0.001) and smaller PP amplification (beta = -0.092, P < 0.001) were identified as independent determinants of narrowing of CRAE in the same equation, which indicated the superiority of central BP. Central BP-determined hypertensive individuals had a significantly narrower CRAE independent of brachial BP (central/brachial: hypertension/hypertension 121.4 +/- 11.5, hypertension/normotension 120.9 +/- 11.2, normotension/ hypertension 125.1 +/- 11.9, normotension/normotension 128.1 +/- 11.5 mu m). Conclusion: Central BP was more closely associated with the narrowing of CRAE than brachial BP. Slight increases in central BP might be involved in the morphological changes in small retinal arteries, even in individuals with optimal brachial BP.
引用
收藏
页码:323 / 329
页数:7
相关论文
共 50 条
[41]   Evaluation of a Brachial Cuff and Suprasystolic Waveform Algorithm Method to Noninvasively Derive Central Blood Pressure [J].
Costello, Benedict T. ;
Schultz, Martin G. ;
Black, J. Andrew ;
Sharman, James E. .
AMERICAN JOURNAL OF HYPERTENSION, 2015, 28 (04) :480-486
[42]   Risk Stratification by Cross-Classification of Central and Brachial Systolic Blood Pressure [J].
Cheng, Yi-Bang ;
Thijs, Lutgarde ;
Aparicio, Lucas S. ;
Huang, Qi-Fang ;
Wei, Fang-Fei ;
Yu, Yu-Ling ;
Barochiner, Jessica ;
Sheng, Chang-Sheng ;
Yang, Wen-Yi ;
Niiranen, Teemu J. ;
Boggia, Jose ;
Zhang, Zhen-Yu ;
Stolarz-Skrzypek, Katarzyna ;
Gilis-Malinowska, Natasza ;
Tikhonoff, Valerie ;
Wojciechowska, Wiktoria ;
Casiglia, Edoardo ;
Narkiewicz, Krzysztof ;
Filipovsky, Jan ;
Kawecka-Jaszcz, Kalina ;
Wang, Ji-Guang ;
Li, Yan ;
Staessen, Jan A. .
HYPERTENSION, 2022, 79 (05) :1101-1111
[43]   Determination of central blood pressure by a noninvasive method (brachial BP and QKD interval) [J].
Cremer, Antoine ;
Butlin, Mark ;
Codjo, Leopold ;
Coulon, Paul ;
Ranouil, Xavier ;
Joret, Cedric ;
Coste, Pierre ;
Asmar, Roland ;
Avolio, Alberto ;
Gosse, Philippe .
JOURNAL OF HYPERTENSION, 2012, 30 (08) :1533-1539
[44]   Evaluation of a novel sphygmomanometer, which estimates central aortic blood pressure from analysis of brachial artery suprasystolic pressure waves [J].
Lin, Aaron C. W. ;
Lowe, Andrew ;
Sidhu, Karishma ;
Harrison, Wil ;
Ruygrok, Peter ;
Stewart, Ralph .
JOURNAL OF HYPERTENSION, 2012, 30 (09) :1743-1750
[45]   Measurement of Central Systolic Blood Pressure by Pulse Volume Plethysmography With a Noninvasive Blood Pressure Monitor [J].
Sung, Shih-Hsien ;
Cheng, Hao-Min ;
Chuang, Shao-Yuan ;
Shih, Yuan-Ta ;
Wang, Kang-Ling ;
Chen, Ying-Hwa ;
Lin, Shing-Jong ;
Yu, Wen-Chung ;
Chen, Chen-Huan .
AMERICAN JOURNAL OF HYPERTENSION, 2012, 25 (05) :542-548
[46]   Novel Description of the 24-Hour Circadian Rhythms of Brachial Versus Central Aortic Blood Pressure and the Impact of Blood Pressure Treatment in a Randomized Controlled Clinical Trial The Ambulatory Central Aortic Pressure (AmCAP) Study [J].
Williams, Bryan ;
Lacy, Peter S. ;
Baschiera, Fabio ;
Brunel, Patrick ;
Duesing, Rainer .
HYPERTENSION, 2013, 61 (06) :1168-+
[47]   Older age is associated with greater central aortic blood pressure following the exercise stress test in subjects with similar brachial systolic blood pressure [J].
Masatake Kobayashi ;
Kazutaka Oshima ;
Yoichi Iwasaki ;
Yuto Kumai ;
Alberto Avolio ;
Akira Yamashina ;
Kenji Takazawa .
Heart and Vessels, 2016, 31 :1354-1360
[48]   Association between blood pressure and retinal arteriolar and venular diameters in Chinese early adolescent children, and whether the association has gender difference: a cross-sectional study [J].
He, Yuan ;
Li, Shi-Ming ;
Kang, Meng-Tian ;
Liu, Luo-Ru ;
Li, He ;
Wei, Shi-Fei ;
Ran, An-Ran ;
Wang, Ningli .
BMC OPHTHALMOLOGY, 2018, 18
[49]   Evaluation of Central Blood Pressure in an Asian Population: Comparison between Brachial Oscillometry and Radial Tonometry Methods [J].
Hoshide, Satoshi ;
Komori, Takahiro ;
Ogata, Yukiyo ;
Eguchi, Kazuo ;
Kario, Kazuomi .
PULSE, 2018, 6 (1-2) :98-102
[50]   Estimation of central systolic blood pressure using an oscillometric blood pressure monitor [J].
Cheng, Hao-Min ;
Wang, Kang-Ling ;
Chen, Ying-Hwa ;
Lin, Shing-Jong ;
Chen, Lung-Ching ;
Sung, Shih-Hsien ;
Ding, Philip Yu-An ;
Yu, Wen-Chung ;
Chen, Jaw-Wen ;
Chen, Chen-Huan .
HYPERTENSION RESEARCH, 2010, 33 (06) :592-599