Dendritic cell-based cancer immunotherapy for colorectal cancer

被引：31
作者：
Kajihara, Mikio [1 ]
Takakura, Kazuki [1 ]
Kanai, Tomoya [1 ]
Ito, Zensho [1 ]
Saito, Keisuke [1 ]
Takami, Shinichiro [1 ]
Shimodaira, Shigetaka [2 ]
Okamoto, Masato [3 ]
Ohkusa, Toshifumi [1 ,4 ]
Koido, Shigeo [1 ,4 ]
机构：
[1] Jikei Univ, Sch Med, Kashiwa Hosp, Div Gastroenterol & Hepatol,Dept Internal Med, 163-1 Kashiwashita, Kashiwa, Chiba 2778567, Japan
[2] Shinshu Univ Hosp, Cell Proc Ctr, Nagano 3908621, Japan
[3] Kitasato Univ, Sch Pharm, Dept Adv Immunotherapeut, Tokyo 1088641, Japan
[4] Jikei Univ, Sch Med, Inst Clin Med & Res, Chiba 2778567, Japan
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2016年 / 22卷 / 17期
关键词：
Colorectal cancer; Dendritic cell; Cancer immunotherapy; Cytotoxic T lymphocyte; Immune-checkpoint inhibitors; MISMATCH-REPAIR DEFICIENCY; CYTOTOXIC T-LYMPHOCYTES; RESPONSES IN-VITRO; TUMOR GENE WT1; CARCINOEMBRYONIC-ANTIGEN; ANTITUMOR IMMUNITY; PHASE-I; GASTROINTESTINAL CARCINOMAS; PANCREATIC-CANCER; MELANOMA PATIENTS;
D O I：
10.3748/wjg.v22.i17.4275
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Colorectal cancer (CRC) is one of the most common cancers and a leading cause of cancer-related mortality worldwide. Although systemic therapy is the standard care for patients with recurrent or metastatic CRC, the prognosis is extremely poor. The optimal sequence of therapy remains unknown. Therefore, alternative strategies, such as immunotherapy, are needed for patients with advanced CRC. This review summarizes evidence from dendritic cell-based cancer immunotherapy strategies that are currently in clinical trials. In addition, we discuss the possibility of antitumor immune responses through immunoinhibitory PD-1/PD-L1 pathway blockade in CRC patients.
引用
收藏
页码：4275 / 4286
页数：12
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