Disrupted network connectivity in pediatric brain tumor survivors is a signature of injury

被引:10
作者
Gauvreau, Samantha [1 ,2 ]
Lefebvre, Jeremie [3 ,4 ]
Bells, Sonya [1 ]
Laughlin, Suzanne [5 ,6 ]
Bouffet, Eric [7 ,8 ]
Mabbott, Donald J. [1 ,2 ]
机构
[1] Hosp Sick Children, Res Inst, Neurosci & Mental Hlth Program, 686 Bay St, Toronto, ON, Canada
[2] Univ Toronto, Dept Psychol, Toronto, ON, Canada
[3] Univ Hlth Network, Krembil Res Inst, Toronto, ON, Canada
[4] Univ Toronto, Dept Math, Toronto, ON, Canada
[5] Hosp Sick Children, Dept Diagnost Imaging, Diagnost Imaging, Toronto, ON, Canada
[6] Univ Toronto, Dept Med Imaging, Med Imaging, Toronto, ON, Canada
[7] Hosp Sick Children, Div Haematol Oncol, Toronto, ON, Canada
[8] Univ Toronto, Dept Paediat, Toronto, ON, Canada
基金
加拿大健康研究院;
关键词
brain tumor; CANTAB RRID:SCR_003001); computational modeling; Fieldtrip toolbox RRID: SCR_004849; functional connectivity; magnetoencephalography; network based statistics toolbox RRID:SCR_002454; neural network; pediatric; FUNCTIONAL CONNECTIVITY; WHITE-MATTER; COMPONENT ANALYSIS; CORTICAL NETWORKS; CHILDHOOD; MEG; OSCILLATIONS; DEFICITS; SYNCHRONIZATION; INTEGRATION;
D O I
10.1002/cne.24717
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Cognition is compromised in pediatric brain tumor survivors but the neurophysiological basis of this compromise remains unclear. We hypothesized that reduced neural synchronization across brain networks is involved. To test this, we evaluated group differences using a retrospective cohort comparison design between 24 pediatric brain tumor survivors [11.81 +/- 3.27)] and 24 age matched healthy children [12.04 +/- 3.28)] in functional connectivity within a cerebellar network to examine local effects of the tumor, a whole brain network to examine diffuse effects of treatment (i.e., chemotherapy and radiation), and across multiple intrinsic connectivity networks. Neural activity was recorded during magnetoencephalography scanning while participants were at rest and functional connectivity within networks was measured using the phase lag index. We corroborated our findings using a computational model representing the local tumor effects on neural synchrony. Compared to healthy children, pediatric brain tumor survivors show increased functional connectivity for theta and beta frequency bands within the cerebellar network and increased functional connectivity for the theta band within the whole brain network that again localized to the cerebellum. Computational modeling showed that increased synchrony in the theta bad is observed following local clustering as well as sparse interarea brain connectivity. We also observed increased functional connectivity for the alpha frequency band in the ventral attention network and decreased functional connectivity within the gamma frequency band in the motor network within paedatric brain tumor survivors versus healthy children. Notably, increased gamma functional connectivity within the motor network predicted decreased reaction time on behavioral tasks in pediatric brain tumor survivors. Disrupted network synchrony may be a signature of neurological injury and disease.
引用
收藏
页码:2896 / 2909
页数:14
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