In-depth analysis of the long-term processability of materials during continuous feeding

被引:19
作者
Bekaert, B. [1 ]
Van Snick, B. [2 ]
Pandelaere, K. [1 ]
Dhondt, J. [3 ]
Di Pretoro, G. [2 ]
De Beer, T. [3 ]
Vervaet, C. [1 ]
Vanhoorne, V. [1 ]
机构
[1] Univ Ghent, Dept Pharmaceut, Lab Pharmaceut Technol, Ottergemsesteenweg 460, B-9000 Ghent, Belgium
[2] Johnson & Johnson, Oral Solid Dosage Drug Prod Dev, Pharmaceut Res & Dev, Discovery Prod Dev & Supplies,Div Janssen Pharmac, Turnhoutseweg 30, B-2340 Beerse, Belgium
[3] Univ Ghent, Dept Pharmaceut Anal, Lab Pharmaceut Proc Analyt Technol, Ottergemsesteenweg 460, B-9000 Ghent, Belgium
关键词
CONTINUOUS DIRECT COMPRESSION; PLATFORM; TABLETS;
D O I
10.1016/j.ijpharm.2022.121454
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This study determined the feasibility of long-term continuous powder feeding and its effect on the overall process performance. Additionally, quantitative relationships were established between material properties, process settings and screw feeding responses during gravimetric feeding. Twelve divergent raw materials were processed over longer periods using a GEA Compact Feeder integrated in a continuous direct compression line (ConsiGma (TM) CDC-50). The resulting gravimetric feeding responses were combined with the material properties and process settings into an overall PLS model. The model elucidated the impact of the material descriptors for density; powder flow; particle size; compressibility; permeability and wall friction angle on the feeding process. Furthermore, long-term processing of the materials exhibited challenges related to the processability and refill consistency where a significant impact of the compressibility and cohesive/adhesive properties of the materials was observed. Overall, this approach provided insights into the feasibility of long-term continuous feeding which is not possible through 'short-term' feeding trials. Additionally, throughout this study, the need for material-specific adjustments of the feeding and refill equipment was highlighted.
引用
收藏
页数:17
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