Autologus dendritic cell vaccine for chronic hepatitis B carriers: A pilot, open label, clinical trial in human volunteers

被引:48
作者
Luo, Jin [1 ,2 ]
Li, Jun [3 ]
Chen, Rui L. [4 ]
Nie, Lei [5 ]
Huang, Jie [6 ]
Liu, Zheng W. [7 ]
Luo, Lin [8 ]
Yan, Xiao J. [1 ,9 ]
机构
[1] Fourth Mil Med Univ, Inst Genet Diag, Dept Pharmacogenom, Sch Pharm, Xian 710032, Shaanxi, Peoples R China
[2] Taizhou Hepatopathy Ctr, Taizhou City 225300, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Dept Infect Dis, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China
[4] Shaanxi Prov Peoples Hosp, Dept Respirat, Xian 710068, Peoples R China
[5] Xian Med Coll, Dept Pathol, Xian 710032, Shaanxi, Peoples R China
[6] Xi An Jiao Tong Univ, Dept Management Sci & Engn, Sch Management, Xian 710032, Shaanxi, Peoples R China
[7] Xi An Jiao Tong Univ, Dept Infect Dis, Affiliated Hosp 1, Sch Med, Xian 710032, Shaanxi, Peoples R China
[8] Maternal & Child Care Serv Ctr Hanzhong City, Hanzhong 723000, Shaanxi, Peoples R China
[9] Biol Diag & Therapy Engn Res Ctr, Xian 710032, Shaanxi, Peoples R China
基金
中国国家自然科学基金;
关键词
Immunotherapy; Dendritic cell vaccine; Chronic hepatitis B; VIRUS-TRANSGENIC MICE; VIRAL-HEPATITIS; E-ANTIGEN; HBEAG SEROCONVERSION; LAMIVUDINE TREATMENT; THERAPEUTIC VACCINE; ADEFOVIR DIPIVOXIL; ANTIBODY-RESPONSE; INFECTION; EFFICACY;
D O I
10.1016/j.vaccine.2010.01.038
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Antigen-presenting autologous dendritic cells (ADCs), primed with antigen, have been used in immunotherapy. We evaluated ADCs for treatment of chronic hepatitis B (CHB). ADCs were administered to 380 CHB patients. Virological, biochemical, and serological responses were evaluated in each patient over the course of 48 weeks. Undetectable levels of HBV DNA were reported in 46.36% of patients negative for the hepatitis B "e" antigen (HBeAg) and 3.13% HBeAg-positive patients. Normalization of alanine aminotransferase levels occurred in both HBeAg-positive (P=0.007) and HBeAg-negative (P=0.003) patients. It appears that ADC vaccination effectively reconstructed the immunity and elicited virological, serological, and biochemical improvements in some patients with chronic HBV. No side effects were observed. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:2497 / 2504
页数:8
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