Current Trends in Ligand Binding Real-Time Measurement Technologies

被引：8

作者：

Fraser, Stephanie ^{[1
]}

Shih, Judy Y. ^{[2
]}

Ware, Mark ^{[3
]}

O'Connor, Edward ^{[4
]}

Cameron, Mark J. ^{[5
]}

Schwickart, Martin ^{[6
]}

Zhao, Xuemei ^{[7
]}

Regnstrom, Karin ^{[8
]}

机构：

[1] Pfizer, Eastern Point Rd, Groton, CT 06340 USA

[2] Amgen Inc, One Amgen Ctr Dr, Thousand Oaks, CA 91320 USA

[3] Janssen Res & Dev LLC, 1400 McKean Rd, Spring House, PA 19477 USA

[4] AegisBioconsult, 78 Marbern Dr, Suffield, CT 06078 USA

[5] Lumigen, 22900 8 Mile Rd, Southfield, MI 48033 USA

[6] MedImmune, 319 N Bernardo Ave, Mountain View, CA 94043 USA

[7] Merck Res Labs, Rahway, NJ 07065 USA

[8] Boehringer Ingelheim GmbH & Co KG, 6701 Kaiser Dr, Fremont, CA 94555 USA

来源：

AAPS JOURNAL | 2017年 / 19卷 / 03期

关键词：

emergent technology review; lateral flow immunoassay; ligand binding assay; real-time measurement; surface plasmon resonance; SURFACE-PLASMON RESONANCE; LATERAL FLOW IMMUNOASSAY; BIOSENSOR; PROTEIN; AFFINITY; ANTIBODY; CANCER; SERUM; PCR; VALIDATION;

D O I：

10.1208/s12248-017-0067-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Numerous advances in ligand binding assay (LBA) real-time measurement technologies have been made within the last several years, ranging from the development of novel platforms to drive technology expansion to the adaptation of existing platforms to optimize performance and throughput. In this review, we have chosen to focus on technologies that provide increased value to two distinct segments of the LBA community. First, experimentally, by measuring real-time binding events, these technologies provide data that can be used to interrogate receptor/ ligand binding interactions. While overall the platforms are not new, they have made significant advances in throughput, multiplexing, and/or sensitivity. Second, clinically, these point-of-care (POC) technologies provide instantaneous information which facilitates rapid treatment decisions.

引用

页码：682 / 691

页数：10

共 48 条

[1] Detection of Waterborne Viruses Using High Affinity Molecularly Imprinted Polymers [J].