Comparative speed of kill between nitenpyram, fipronil, imidacloprid, selamectin and cythioate against adult Ctenocephalides felis (Bouche) on cats and dogs

Speed of kill and percentage kill of nitenpyram (CAPSTAR(R)) was compared to fipronil (Frontline(R) spot-on), imidacloprid (Bayvantage(R)/Advantage(TM)), selamectin (Stronghold(TM)/Revolution(TM)) and cythioate (Cyflee(R)) against adult fleas on cats and dogs 3 and 8 h post-treatment. Selamectin was used on dogs only; cythioate was used on cats only. Groups of eight cats and eight dogs (four males and four females each) were experimentally infested with 100 unfed fleas 1 day prior to treatment with the test products. One group of cats and one group of dogs served as control. Fleas were collected from four cats and four dogs in each group (two males and two females) by combing 3 h after treatment, the remaining four cats or dogs were combed 8 It after treatment. In cats cythioate treatment resulted in a mean efficacy of 62.4 and 97.4% at 3 and 8 h post-treatment, respectively. Imidacloprid efficacy at the same times was 26.9 and 82.8%, whereas fipronil efficacy was 24.3 and 62.6% efficacy, respectively. In dogs mean efficacy 3 and 8 It after treatment with selamectin was 39.7 and 74.4%; with imidacloprid efficacy was 22.2 and 95.7%, respectively and 35.9 and 46.5%, respectively after treatment with fipronil. Nitenpyram was 100% effective in cats and 99.1% effective in dogs within 3 h of treatment and 100% effective in cats and dogs within 8 h. (C) 2002 Elsevier Science B.V. All rights reserved.