Opioids and Cannabinoids Interactions: Involvement in Pain Management

被引:43
作者
Desroches, Julie [2 ]
Beaulieu, Pierre [1 ,2 ]
机构
[1] Univ Montreal, CHUM, Hotel Dieu, Dept Anesthesiol,Fac Med, Montreal, PQ H2W 1T8, Canada
[2] Univ Montreal, CHUM, Fac Med, Dept Pharmacol, Montreal, PQ H2W 1T8, Canada
关键词
Opioids; Cannabinoids; Antinociception; Bidirectional interactions; Synergism; Clinical implications; RECEPTOR KNOCKOUT MICE; IN-SITU HYBRIDIZATION; RAT SPINAL-CORD; SUBSTANTIA-GELATINOSA NEURONS; ACID AMIDE HYDROLASE; VANILLOID TYPE-1 RECEPTORS; STRESS-INDUCED ANALGESIA; CENTRAL-NERVOUS-SYSTEM; MESSENGER-RNA LEVELS; DORSAL-ROOT GANGLIA;
D O I
10.2174/138945010790980303
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Among several pharmacological properties, analgesia is the most common feature shared by either opioid or cannabinoid systems. Cannabinoids and opioids are distinct drug classes that have been historically used separately or in combination to treat different pain states. Indeed, it is widely known that activation of either opioid or cannabinoid systems produces antinociceptive properties in different pain models. Moreover, several biochemical, molecular and pharmacological studies support the existence of reciprocal interactions between both systems, suggesting a common underlying mechanism. Further studies have demonstrated that the endogenous opioid system could be involved in cannabinoid antinociception and recent data have also provided evidence for a role of the endogenous cannabinoid system in opioid antinociception. These interactions may lead to additive or even synergistic antinociceptive effects, emphasizing their clinical relevance in humans in order to enhance analgesic effects with lower doses and consequently fewer undesirable side effects. Thus, the present review is focused on bidirectional interactions between opioids and cannabinoids and their potent repercussions on pain modulation.
引用
收藏
页码:462 / 473
页数:12
相关论文
共 203 条
[81]   SPINAL OPIOID ANALGESIC EFFECTS ARE ENHANCED IN A MODEL OF UNILATERAL INFLAMMATION HYPERALGESIA - POSSIBLE INVOLVEMENT OF NORADRENERGIC MECHANISMS [J].
HYLDEN, JLK ;
THOMAS, DA ;
IADAROLA, MJ ;
NAHIN, RL ;
DUBNER, R .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 194 (2-3) :135-143
[82]   CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids [J].
Ibrahim, MM ;
Porreca, F ;
Lai, J ;
Albrecht, PJ ;
Rice, FL ;
Khodorova, A ;
Davar, G ;
Makriyannis, A ;
Vanderah, TW ;
Mata, HP ;
Malan, TP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (08) :3093-3098
[83]   CB2 cannabinoid receptor mediation of antinociception [J].
Ibrahim, Mohab M. ;
Rude, Megan L. ;
Stagg, Nicola J. ;
Mata, Heriberto P. ;
Lai, Josephine ;
Vanderah, Todd W. ;
Porreca, Frank ;
Buckley, Nancy E. ;
Makriyannis, Alexandros ;
Malan, T. Philip, Jr. .
PAIN, 2006, 122 (1-2) :36-42
[84]   Regulation of Pain Sensitivity in Experimental Osteoarthritis by the Endogenous Peripheral Opioid System [J].
Inglis, Julia J. ;
McNamee, Kay E. ;
Chia, Shi-Lu ;
Essex, David ;
Feldmann, Marc ;
Williams, Richard O. ;
Hunt, Stephen P. ;
Vincent, Tonia .
ARTHRITIS AND RHEUMATISM, 2008, 58 (10) :3110-3119
[85]   The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain [J].
Jaggar, SI ;
Hasnie, FS ;
Sellaturay, S ;
Rice, ASC .
PAIN, 1998, 76 (1-2) :189-199
[86]   Endomorphins as agents for the treatment of chronic inflammatory disease [J].
Jessop, David S. .
BIODRUGS, 2006, 20 (03) :161-166
[87]   Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain [J].
Jhaveri, M. D. ;
Richardson, D. ;
Chapman, V. .
BRITISH JOURNAL OF PHARMACOLOGY, 2007, 152 (05) :624-632
[88]   Cannabinoid CB2 receptor-mediated anti-nociception in models of acute and chronic pain [J].
Jhaveri, Maulik D. ;
Sagar, Devi R. ;
Elmes, Steven J. R. ;
Kendall, David A. ;
Chapman, Victoria .
MOLECULAR NEUROBIOLOGY, 2007, 36 (01) :26-35
[89]   Modulation of anxiety through blockade of anandamide hydrolysis [J].
Kathuria, S ;
Gaetani, S ;
Fegley, D ;
Valiño, F ;
Duranti, A ;
Tontini, A ;
Mor, M ;
Tarzia, G ;
La Rana, G ;
Calignano, A ;
Giustino, A ;
Tattoli, M ;
Palmery, M ;
Cuomo, V ;
Piomelli, D .
NATURE MEDICINE, 2003, 9 (01) :76-81
[90]   Regulation of human epidermal melanocyte biology by β-endorphin [J].
Kauser, S ;
Schallreuter, KU ;
Thody, AJ ;
Gummer, C ;
Tobin, DJ .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2003, 120 (06) :1073-1080