Restoring Endogenous Repair Mechanisms to Heal Chronic Wounds with a Multifunctional Wound Dressing

被引：20

作者：

Atashgah, Rahimeh B. ^{[1
,2
,3
,4
]}

Ghasemi, Amir ^{[5
]}

Raoufi, Mohammad ^{[5
,22
,23
]}

Abdollahifar, Mohammad-Amin ^{[6
]}

Zanganeh, Steven ^{[7
]}

Nejadnik, Hossein ^{[8
]}

Abdollahi, Alieh ^{[3
,4
]}

Sharifi, Shahriar ^{[9
]}

Lea, Baltazar ^{[1
,2
]}

Cuerva, Miguel ^{[10
]}

Akbarzadeh, Mehdi ^{[11
]}

Alvarez-Lorenzo, Carmen ^{[2
,12
]}

Ostad, Seyed Nasser ^{[3
,4
]}

Theus, Andrea S. ^{[13
,14
]}

LaRock, Doris L. ^{[15
]}

LaRock, Christopher N. ^{[15
]}

Serpooshan, Vahid ^{[13
,14
,16
,17
]}

Sarrafi, Rouzbeh ^{[18
]}

Lee, Ki-Bum ^{[19
]}

Vali, Hojatollah ^{[20
,21
]}

Schoenherr, Holger ^{[22
,23
]}

Gould, Lisa ^{[24
,25
]}

Taboada, Pablo ^{[1
,2
]}

Mahmoudi, Morteza ^{[9
,26
,27
]}

机构：

[1] Univ Santiago de Compostela, Fac Phys, Particle Phys Dept, Colloids & Polymers Phys Grp, Santiago De Compostela 15782, Spain

[2] Univ Santiago de Compostela, Hlth Res Inst Santiago de Compostela IDIS, Santiago De Compostela 15782, Spain

[3] Univ Tehran Med Sci, Fac Pharm, Dept Pharmaceut Biomat, Tehran 1416753955, Iran

[4] Univ Tehran Med Sci, Med Biomat Res Ctr, Fac Pharm, Tehran 1416753955, Iran

[5] Univ Tehran Med Sci, Fac Pharm, Nanotechnol Res Ctr, Tehran 1316943551, Iran

[6] Shahid Beheshti Univ Med Sci, Sch Med, Dept Biol & Anat Sci, Tehran 193954719, Iran

[7] Univ Massachusetts, Dept Bioengn, Dartmouth, MA 02747 USA

[8] Univ Penn, Dept Radiol, Philladelphia, PA 19104 USA

[9] Michigan State Univ, Precis Hlth Program, E Lansing, MI 48824 USA

[10] Univ Santiago de Compostela USC, Technol Res Inst IIT, Phys Chem Dept, NANOMAG Grp, Santiago De Compostela 15782, Spain

[11] Sadra Wound Ost & Osteomyelitis Specialist Ctr, Tehran, Iran

[12] Univ Santiago de Compostela, RD Pharma Grp, Pharmacol Pharm & Pharmaceut Technol Dept, Fac Pharm, Santiago De Compostela 15782, Spain

[13] Emory Univ, Wallace H Coulter Dept Biomed Engn, Sch Med, Atlanta, GA 30322 USA

[14] Georgia Inst Technol, Atlanta, GA 30322 USA

[15] Emory Univ, Emory Antibiot Resistance Ctr, Dept Microbiol & Immunol, Sch Med, Atlanta, GA 30322 USA

[16] Emory Univ, Dept Pediat, Sch Med, Atlanta, GA 30309 USA

[17] Childrens Healthcare Atlanta, Atlanta, GA 30322 USA

[18] SciDerm, Natick, MA USA

[19] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

[20] McGill Univ, Dept Anat & Cell Biol, Montreal, PQ H3A 0C3, Canada

[21] McGill Univ, Facil Electron Microscopy Res, Montreal, PQ H3A 0C3, Canada

[22] Univ Siegen, Phys Chem 1, Dept Chem & Biol, D-57076 Siegen, Germany

[23] Univ Siegen, Res Ctr Micro & Nanochem & Engn C, D-57076 Siegen, Germany

[24] Brown Univ, Sch Med, Providence, RI 02903 USA

[25] South Shore Hlth Syst Ctr Wound Healing, Weymouth, MA 02189 USA

[26] Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA

[27] Harvard Med Sch, Mary Horrigan Connors Ctr Womens Hlth & Gender Bi, Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

MOLECULAR PHARMACEUTICS | 2021年 / 18卷 / 08期

基金：

美国国家科学基金会;

关键词：

chronic wounds; multifunctional wound dressing; nanomedicine; endogenous repair; ANTIBACTERIAL PROPERTIES; HYALURONIC-ACID; MATRIX METALLOPROTEINASES; I COLLAGEN; CHITOSAN; NANOPARTICLES; EXPRESSION; ANGIOGENESIS; GROWTH; INFLAMMATION;

D O I：

10.1021/acs.molpharmaceut.1c00400

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Current treatment of chronic wounds has been critically limited by various factors, including bacterial infection, biofilm formation, impaired angiogenesis, and prolonged inflammation. Addressing these challenges, we developed a multifunctional wound dressing-based three-pronged approach for accelerating wound healing. The multifunctional wound dressing, composed of nanofibers, functional nanoparticles, natural biopolymers, and selected protein and peptide, can target multiple endogenous repair mechanisms and represents a promising alternative to current wound healing products.

引用

页码：3171 / 3180

页数：10

共 73 条

[1] COLLAGENASE IN WOUND-HEALING - EFFECT OF WOUND AGE AND TYPE
AGREN, MS
TAPLIN, CJ
WOESSNER, JF
EAGLSTEIN, WH
MERTZ, PM
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1992, 99 (06) : 709 - 714
[2] Anti-Inflammatory Effects of Intra-Articular Hyaluronic Acid: A Systematic Review
Altman, Roy
Bedi, Asheesh
Manjoo, Ajay
Niazi, Faizan
Shaw, Peter
Mease, Philip
[J]. CARTILAGE, 2019, 10 (01) : 43 - 52
[3] [Anonymous], 2019, I CORPS MULTIFUNCTIO
[4] [Anonymous], LANCET, DOI DOI 10.1016/S0140-6736(16)00618-8
[5] The bright and the dark sides of activin in wound healing and cancer
Antsiferova, Maria
Werner, Sabine
[J]. JOURNAL OF CELL SCIENCE, 2012, 125 (17) : 3929 - 3937
[6] The role of matrix metalloproteinases in wound healing
Armstrong, DG
Jude, EB
[J]. JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION, 2002, 92 (01) : 12 - 18
[7] Skin substitutes: a review
Balasubramani, M
Kumar, TR
Babu, M
[J]. BURNS, 2001, 27 (05) : 534 - 544
[8] Growth factors and cytokines in wound healing
Barrientos, Stephan
Stojadinovic, Olivera
Golinko, Michael S.
Brem, Harold
Tomic-Canic, Marjana
[J]. WOUND REPAIR AND REGENERATION, 2008, 16 (05) : 585 - 601
[9] Tissue-engineered skin: Current status in wound healing
Bello Y.M.
Falabella A.F.
Eaglstein W.H.
[J]. American Journal of Clinical Dermatology, 2001, 2 (5) : 305 - 313
[10] Wound healing dressings and drug delivery systems: A review
Boateng, Joshua S.
Matthews, Kerr H.
Stevens, Howard N. E.
Eccleston, Gillian M.
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 97 (08) : 2892 - 2923

← 1 2 3 4 5 6 7 8 →