Topical chemotherapy for ocular surface squamous neoplasia: current status

被引：43

作者：

Sepulveda, Ricardo

Pe'er, Jacob ^{[2
]}

Midena, Edoardo ^{[3
]}

Seregard, Stefan ^{[4
]}

Dua, Harminder S. ^{[5
]}

Singh, Arun D. ^{[1
]}

机构：

[1] Cleveland Clin, Cole Eye Inst, Dept Ophthalm Oncol, 9500 Euclid Ave, Cleveland, OH 44195 USA

[2] Hadassah Univ Hosp, Dept Ophthalmol, IL-91120 Jerusalem, Israel

[3] Univ Padua, Dept Ophthalmol, Padua, Italy

[4] Karolinska Univ, St Eriks Eye Hosp, Stockholm, Sweden

[5] Univ Nottingham, Div Ophthalmol & Visual Sci, Nottingham NG7 2RD, England

来源：

BRITISH JOURNAL OF OPHTHALMOLOGY | 2010年 / 94卷 / 05期

关键词：

CORNEAL INTRAEPITHELIAL NEOPLASIA; TERM-FOLLOW-UP; MITOMYCIN-C; CLINICAL-APPLICATIONS; EPITHELIAL DYSPLASIA; CONJUNCTIVAL; 5-FLUOROURACIL; INTERFERON; PROLIFERATION; FLUOROURACIL;

D O I：

10.1136/bjo.2009.160820

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Although there are no randomised trials directly comparing topical chemotherapeutic agents mitomycin-C, 5-fluorouracil, and interferon-alpha 2b, published studies indicate equal efficacy of these agents for treatment of non-invasive ocular surface squamous neoplasia (80%-88%). 5-Fluorouracil may be preferred, given low incidence of serious side effects and low cost to the patient.

引用

页码：532 / 535

页数：4

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