Preparation, characterization, and antibacterial activity evaluation of collagen-Zn complex

被引：1

作者：

Liu, Huiyun ^{[1
]}

Wang, Shizheng ^{[2
]}

Xi, Yu ^{[2
]}

Liu, Pu ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Chem, Zhengzhou 450001, Peoples R China

[2] Zhengzhou Univ, Dept Bioengn, Zhengzhou 450001, Peoples R China

来源：

POLYMER BULLETIN | 2010年 / 64卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Collagen protein; Complex; Characterization; Antibacterial activity; CROSS-LINKING; SILVER; CELLS; MODEL;

D O I：

10.1007/s00289-009-0228-7

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The different kinds of collagen-Zn complexes were prepared by zinc acetate, zinc chloride, zinc nitrate, and zinc sulfate reacted with collagen protein. Their antibacterial activities have been investigated by MIC method. It was found that the antibacterial activity of collagen-ZnSO4 complex is better than that of others. To obtain a better antibacterial activity, collagen-ZnSO4 complexes with different zinc amount were prepared using zinc sulfate as starting material. These complexes were characterized by FT-IR, XRD, and atomic absorption spectrometry. The results showed that zinc ion could chelate with N-H, C-O, and C=O group in collagen to form the stable complex. Antibacterial activities of collagen-ZnSO4 complexes containing different Zn amount were evaluated against Escherichia coli and Staphylococcus aureus. The results suggested that antibacterial activity increases with the increase of zinc amount.

引用

页码：835 / 843

页数：9

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