Outcomes of right-sided and left-sided colon cancer after curative resection

被引：18
作者：
Yang, Chien-Yi [1 ]
Yen, Min-Hsuan [2 ]
Kiu, Kee-Thai [2 ]
Chen, Yu-Ting [2 ]
Chang, Tung-Cheng [2 ,3 ]
机构：
[1] Taipei Med Univ, Shuang Ho Hosp, Dept Surg, 291 Zhongzheng Rd, New Taipei 235, Taiwan
[2] Taipei Med Univ, Shuang Ho Hosp, Dept Surg, Div Colorectal Surg, 291 Zhongzheng Rd, New Taipei 235, Taiwan
[3] Taipei Med Univ, Coll Med, Sch Med, Dept Surg, New Taipei, Taiwan
来源：
SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期
关键词：
COLORECTAL-CANCER; MISMATCH REPAIR; SURVIVAL; RECURRENCE; MORTALITY; IMPACT; EPIDEMIOLOGY; DIFFERENCE; SURGERY; OBESITY;
D O I：
10.1038/s41598-022-15571-2
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The right and left side of the colon derived from the midgut and hindgut, respectively. Previous studies have reported different characteristics of right-sided colon cancer (RCC) and left-sided colon cancer (LCC), but oncological outcomes remain unclear. This study compared the outcomes of RCC and LCC. This retrospective study included 1017 patients who received curative colectomy for stage I-III colon cancer at a single institute between August 2008 and December 2019. Overall survival (OS) and time to recurrence (TTR) were analyzed as outcome measurements. No significant difference in the OS or TTR of patients with RCC and LCC were observed. In subgroup analysis, RCC was associated with shorter TTR than LCC in stage II colon cancer (HR 2.36, 95% confidence interval 1.24-4.48, p < 0.01). Multivariate analysis demonstrated that right sidedness, R1 resection, low body mass index (BMI) and adjuvant chemotherapy were independent factors for poor prognosis for stage II colon cancer. Low BMI, perineural invasion, higher T stage and N2 stage were independent factors for poor prognosis for stage III colon cancer. The results were confirmed by multivariate analysis after propensity score matching. Our study revealed that RCC was an independent risk factor for recurrence in stage II colon cancer.
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页数：16
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