Application of copper(i) salt and fluoride promoted Stille coupling reactions in the synthesis of bioactive molecules

被引：27
作者：
Lee, Victor [1 ]
机构：
[1] Univ Oxford, Dept Chem, Chem Res Lab, 12 Mansfield Rd, Oxford OX1 3TA, England
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 41期
关键词：
RADICAL ALKYNE HYDROSTANNATION; FORMAL TOTAL-SYNTHESIS; ALDOL REACTIONS; EFFICIENT SYNTHESIS; ORGANOTIN COMPOUNDS; 9Z-RETINOIC ACID; TERMINAL ALKYNES; NATURAL-PRODUCT; ORGANIC HALIDES; ALDEHYDES;
D O I：
10.1039/c9ob01602c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Stille coupling between organostannanes and organohalides is an effective catalytic method for organic synthesis. Despite the ample amount of published results in this area, finding the optimal conditions for this transformation is often not straightforward. It was observed that this reaction could be accelerated with improved efficiency by the addition of a Cu(i) salt and fluoride. This review summarises the application of this simple protocol in the synthesis of natural products, their analogues and other biologically active molecules, from 2004 to 2018.
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收藏
页码：9095 / 9123
页数：29
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