ICM0201, a new inhibitor of osteoclastogenesis from Cunninghamella sp F-1490I.: Taxonomy, fermentation, isolation and biological activities

被引：5

作者：

Inoue, H

Kumagai, H

Osono, M

Matsufuji, M

Sameshima, T

Kawamura, N

Someno, T

Ishizuka, M

Takeuchi, T

机构：

[1] MCRF, Inst Chemotherapy, Shizuoka 4100301, Japan

[2] Mercian Co Ltd, Bioresource Res Labs, Fujisawa, Kanagawa 2510057, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 03期

关键词：

D O I：

10.7164/antibiotics.56.209

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In the course of screening for inhibitors of osteoclastogenesis, a new substance designated as ICM0201 was isolated from a fermentation broth of Cunninghamella sp. F-1490. ICM0201 inhibited the formation of osteoclasts in mouse bone marrow cells with an IC50 value of 0.78 mug/ml and showed weak cytotoxicity against bone marrow cells.

引用

收藏

页码：209 / 213

页数：5

相关论文

共 22 条

[1] A NEW RAPID AND SIMPLE NONRADIOACTIVE ASSAY TO MONITOR AND DETERMINE THE PROLIFERATION OF LYMPHOCYTES - AN ALTERNATIVE TO [H-3] THYMIDINE INCORPORATION ASSAY [J].

AHMED, SA ;

GOGAL, RM ;

WALSH, JE .

JOURNAL OF IMMUNOLOGICAL METHODS, 1994, 170 (02) :211-224

[2] PARATHYROID-HORMONE (PTH)-RELATED PROTEIN IS A POTENT STIMULATOR OF OSTEOCLAST-LIKE MULTINUCLEATED CELL-FORMATION TO THE SAME EXTENT AS PTH IN MOUSE MARROW CULTURES [J].

AKATSU, T ;

TAKAHASHI, N ;

UDAGAWA, N ;

SATO, K ;

NAGATA, N ;

MOSELEY, JM ;

MARTIN, TJ ;

SUDA, T .

ENDOCRINOLOGY, 1989, 125 (01) :20-27

[3] Current concepts review - Cellular biology of bone-resorbing cells [J].

Athanasou, NA .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1996, 78A (07) :1096-1112

[4]

COLLINS DA, 1991, J BONE MINER RES, V6, P157

[5]

Kornerup A, 1978, METHUEN HDB COLOUR

[6]

Kurihara N, 1998, EXP HEMATOL, V26, P1080

[7] IDENTIFICATION OF COMMITTED MONONUCLEAR PRECURSORS FOR OSTEOCLAST-LIKE CELLS FORMED IN LONG-TERM HUMAN MARROW CULTURES [J].

KURIHARA, N ;

CHENU, C ;

MILLER, M ;

CIVIN, C ;

ROODMAN, GD .

ENDOCRINOLOGY, 1990, 126 (05) :2733-2741

[8] BONE ACID-PHOSPHATASE - TARTRATE-RESISTANT ACID-PHOSPHATASE AS A MARKER OF OSTEOCLAST FUNCTION [J].

MINKIN, C .

CALCIFIED TISSUE INTERNATIONAL, 1982, 34 (03) :285-290

[9] THE EFFECTS OF PARATHYROID-HORMONE (PTH) AND PTH-RELATED PEPTIDE ON OSTEOCLAST RESORPTION OF BONE SLICES INVITRO - AN ANALYSIS OF PIT SIZE AND THE RESORPTION FOCUS [J].

MURRILLS, RJ ;

STEIN, LS ;

FEY, CP ;

DEMPSTER, DW .

ENDOCRINOLOGY, 1990, 127 (06) :2648-2653

[10] PGE2 STIMULATES BOTH RESORPTION AND FORMATION OF BONE INVITRO - DIFFERENTIAL RESPONSES OF THE PERIOSTEUM AND THE ENDOSTEUM IN FETAL-RAT LONG-BONE CULTURES [J].

NEFUSSI, JR ;

BARON, R .

ANATOMICAL RECORD, 1985, 211 (01) :9-16