Pathogenesis of bovine brucellosis

被引：162

作者：

Neta, Alcina V. Carvalho ^{[1
,2
]}

Mol, Juliana P. S. ^{[1
]}

Xavier, Mariana N. ^{[1
]}

Paixao, Tatiane A. ^{[1
]}

Lage, Andrey P. ^{[1
]}

Santos, Renato L. ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Escola Vet, BR-30123970 Belo Horizonte, MG, Brazil

[2] Univ Estadual Maranhao, Ssao Luis, MA, Brazil

来源：

VETERINARY JOURNAL | 2010年 / 184卷 / 02期

关键词：

Brucellosis; Brucella abortus; Pathogenesis; Cattle; ABORTUS ROUGH MUTANTS; TOLL-LIKE RECEPTOR-4; INTRACELLULAR BACTERIAL-INFECTION; 2-COMPONENT SYSTEM BVRR/BVRS; DENDRITIC CELL MATURATION; CULTURE-POSITIVE COWS; IV SECRETION SYSTEM; IMMUNE-RESPONSES; NITRIC-OXIDE; NONPROFESSIONAL PHAGOCYTES;

D O I：

10.1016/j.tvjl.2009.04.010

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Bovine brucellosis is one of the most important zoonotic diseases worldwide, and is of particular significance in developing countries. The disease, which results in serious economic losses due to late term abortion, stillborn and weakly calves, is caused by Gram negative coccobacilli bacteria of the genus Brucella. Lesions consist of necrotic placentitis and interstitial mastitis in pregnant cows, and fibrinous pleuritis with interstitial pneumonia in aborted fetuses and newborn calves. This article considers the pathogenesis of Brucella abortus and reviews the ability of the pathogen to invade phagocytic and non-phagocytic host cells, resist the acidified intraphagosomal environment, and inhibit phagosome-lysosome fusion. Significant aspects of innate and adaptive immunity against brucellosis are also discussed. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：146 / 155

页数：10

共 162 条

[1] BOVINE ILEAL DOME LYMPHOEPITHELIAL CELLS - ENDOCYTOSIS AND TRANSPORT OF BRUCELLA-ABORTUS STRAIN-19 [J].

ACKERMANN, MR ;

CHEVILLE, NF ;

DEYOE, BL .

VETERINARY PATHOLOGY, 1988, 25 (01) :28-35

[2] The pathology of brucellosis reflects the outcome of the battle between the host genome and the Brucella genome [J].

Adams, LG .

VETERINARY MICROBIOLOGY, 2002, 90 (1-4) :553-561

[3] Genetic resistance to bacterial diseases of animals [J].

Adams, LG ;

Templeton, JW .

REVUE SCIENTIFIQUE ET TECHNIQUE-OFFICE INTERNATIONAL DES EPIZOOTIES, 1998, 17 (01) :200-219

[4] QUANTITATIVE COMPARISON OF SENSITIVITY OF SEROLOGICAL TESTS FOR BOVINE BRUCELLOSIS TO DIFFERENT ANTIBODY CLASSES [J].

ALLAN, GS ;

CHAPPEL, RJ ;

WILLIAMSON, P ;

MCNAUGHT, DJ .

JOURNAL OF HYGIENE, 1976, 76 (02) :287-298

[5] Transposon-derived Brucella abortus rough mutants are attenuated and exhibit reduced intracellular survival [J].

Allen, CA ;

Adams, LG ;

Ficht, TA .

INFECTION AND IMMUNITY, 1998, 66 (03) :1008-1016

[6] PATHOGENESIS OF PLACENTITIS IN THE GOAT INOCULATED WITH BRUCELLA-ABORTUS .1. GROSS AND HISTOLOGIC LESIONS [J].

ANDERSON, TD ;

MEADOR, VP ;

CHEVILLE, NF .

VETERINARY PATHOLOGY, 1986, 23 (03) :219-226

[7] PATHOGENESIS OF PLACENTITIS IN THE GOAT INOCULATED WITH BRUCELLA-ABORTUS .2. ULTRASTRUCTURAL STUDIES [J].

ANDERSON, TD ;

CHEVILLE, NF ;

MEADOR, VP .

VETERINARY PATHOLOGY, 1986, 23 (03) :227-239

[8] Cyclic β-1,2-glucan is a brucella virulence factor required for intracellular survival [J].

Arellano-Reynoso, B ;

Lapaque, N ;

Salcedo, S ;

Briones, G ;

Ciocchini, AE ;

Ugalde, R ;

Moreno, E ;

Moriyón, I ;

Gorvel, JP .

NATURE IMMUNOLOGY, 2005, 6 (06) :618-625

[9]

BARQUEROCALVO E, 2007, PLOS ONE, V18, pE7

[10] Stable transfection of the bovine NRAMP1 gene into murine RAW264.7 cells:: Effect on Brucella abortus survival [J].

Barthel, R ;

Feng, JW ;

Piedrahita, JA ;

McMurray, DN ;

Templeton, JW ;

Adams, LG .

INFECTION AND IMMUNITY, 2001, 69 (05) :3110-3119

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