Comparison of Oxidative Stress Markers in Type 2 Diabetes: Basal Bolus Therapy versus Twice Daily Premixed Insulin Analogs

被引：3
作者：
Sakamoto, Masaki [1 ,2 ]
Inoue, Gaku [1 ,2 ]
Tsuyusaki, Kaoru [2 ]
Usui, Kensuke [2 ]
Watanabe, Miwako [3 ]
Irie, Junichiro [1 ,4 ]
Atsuda, Koichiro [2 ]
Yamada, Satoru [1 ,4 ]
机构：
[1] Kitasato Inst Hosp, Ctr Diabet, Tokyo, Japan
[2] Kitasato Univ, Sch Pharmaceut Sci, Dept Hosp Pharm, Tokyo 108, Japan
[3] Mareesia Garden Clin, Tokyo, Japan
[4] Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan
来源：
INTERNAL MEDICINE | 2010年 / 49卷 / 05期
关键词：
oxidative stress; insulin therapy; diabetes; POSTPRANDIAL HYPERGLYCEMIA; DAILY INJECTIONS; COMPLICATIONS; HYPERINSULINEMIA; PREVALENCE; MELLITUS;
D O I：
10.2169/internalmedicine.49.2725
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aims Several studies have shown that twice-daily injection of premixed insulin analog (MIX) therapy achieves glycemic control equivalent to that with basal-bolus (BB) therapy. However, glycemic fluctuations that lead to oxidative stress may be associated with the risk of diabetic complications. Therefore, in this study, we compared oxidative stress markers between MIX therapy and BB therapy. Methods In this cross-sectional study, we recruited a total of 37 patients (17 patients in the BB group and 20 patients in the MIX group) and compared urinary 8-isoprostane and urinary 8-hydroxydeoxyguanosine (8-OHdG) levels. Results There were no significant differences in urinary 8-isoprostane (BB vs MIX: 199 +/- 92 pg/mg Cr vs 266 +/- 107 pg/mg Cr) or urinary 8-OHdG (4.7 +/- 1.6 ng/mg Cr vs 5.4 +/- 1.9 ng/mg Cr, respectively). Conclusion These results suggest that MIX is equivalent to BB in terms of glycemic fluctuations and oxidative stress.
引用
收藏
页码：355 / 359
页数：5
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