Decrease in malate dehydrogenase activities in peripheral leucocytes of type 1 diabetic dogs

被引：13

作者：

Arai, T ^{[1
]}

Nakamura, M ^{[1
]}

Magori, E ^{[1
]}

Fukuda, H ^{[1
]}

Sako, T ^{[1
]}

机构：

[1] Nippon Vet & Anim Sci Univ, Dept Vet Sci, Musashino, Tokyo 1808602, Japan

来源：

RESEARCH IN VETERINARY SCIENCE | 2003年 / 74卷 / 02期

关键词：

D O I：

10.1016/S0034-5288(02)00177-7

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The activities of the enzymes involved in the malate-aspartate shuttle were measured in peripheral leucocytes of dogs with type 1 diabetes mellitus. In the diabetic dogs, fasting plasma glucose concentrations were twofold greater than control levels despite insulin injections and the activities of malate dehydrogenase (MDH), which plays a crucial role in the malate-aspartate shuttle, were decreased remarkably. The cytosolic ratio of MDH/lactate dehydrogenase (LDH) activity (M/L ratio) in leucocytes of the diabetic dogs was significantly lower than that of normal control dogs. The decrease of the M/L ratio appeared to reflect depression of energy metabolism in leucocytes of the diabetic dogs. The M/L ratio may be a useful parameter to evaluate metabolic conditions in diabetic dogs. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：183 / 185

页数：3

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