Age-related inflammatory cytokines and disease

被引：467
作者：
Brüünsgaard, H
Pedersen, BK
机构：
[1] Univ Copenhagen, Rigshosp, Dept Infect Dis M7641, DK-2100 Copenhagen, Denmark
[2] Univ Copenhagen, Rigshosp, Copenhagen Muscle Res Ctr, DK-2100 Copenhagen, Denmark
来源：
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2003年 / 23卷 / 01期
关键词：
D O I：
10.1016/S0889-8561(02)00056-5
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Studies have demonstrated that circulating levels of plasma cytokines are influenced greatly by age and that chronic elevated levels of certain cytokines are associated with chronic diseases. This article discusses the origin of age-associated elevations in circulating levels of cytokines, focusing on the multifunctional tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) and their possible biologic effects in age-associated diseases.
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页码：15 / +
页数：26
相关论文
共 169 条
  • [1] EPIDEMIOLOGY OF ASYMPTOMATIC BACTERIURIA IN ELDERLY WOMEN
    ABRUTYN, E
    MOSSEY, J
    LEVISON, M
    BOSCIA, J
    PITSAKIS, P
    KAYE, D
    [J]. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1991, 39 (04) : 388 - 393
  • [2] Community-acquired pneumonia in the elderly: Association of mortality with lack of fever and leukocytosis
    Ahkee, S
    Srinath, L
    Ramirez, J
    [J]. SOUTHERN MEDICAL JOURNAL, 1997, 90 (03) : 296 - 298
  • [3] Inflammation and Alzheimer's disease
    Akiyama, H
    Barger, S
    Barnum, S
    Bradt, B
    Bauer, J
    Cole, GM
    Cooper, NR
    Eikelenboom, P
    Emmerling, M
    Fiebich, BL
    Finch, CE
    Frautschy, S
    Griffin, WST
    Hampel, H
    Hull, M
    Landreth, G
    Lue, LF
    Mrak, R
    Mackenzie, IR
    McGeer, PL
    O'Banion, MK
    Pachter, J
    Pasinetti, G
    Plata-Salaman, C
    Rogers, J
    Rydel, R
    Shen, Y
    Streit, W
    Strohmeyer, R
    Tooyoma, I
    Van Muiswinkel, FL
    Veerhuis, R
    Walker, D
    Webster, S
    Wegrzyniak, B
    Wenk, G
    Wyss-Coray, T
    [J]. NEUROBIOLOGY OF AGING, 2000, 21 (03) : 383 - 421
  • [4] Cognitive impairment and mortality among nonagenarians: The Danish 1905 cohort survey
    Andersen, K
    Nybo, H
    Gaist, D
    Petersen, HC
    McGue, M
    Jeune, B
    Vaupel, JW
    Christensen, K
    [J]. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2002, 13 (03) : 156 - 163
  • [5] Dementia is not inevitable: A population-based study of Danish centenarians
    Andersen-Ranberg, K
    Vasegaard, L
    Jeune, B
    [J]. JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES, 2001, 56 (03): : P152 - P159
  • [6] Healthy centenarians do not exist, but autonomous centenarians do: A population-based study of morbidity among Danish centenarians
    Andersen-Ranberg, K
    Schroll, M
    Jeune, B
    [J]. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2001, 49 (07) : 900 - 908
  • [7] [Anonymous], HUMAN CYTOKINES THEI
  • [8] HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine
    Asea, A
    Kraeft, SK
    Kurt-Jones, EA
    Stevenson, MA
    Chen, LB
    Finberg, RW
    Koo, GC
    Calderwood, SK
    [J]. NATURE MEDICINE, 2000, 6 (04) : 435 - 442
  • [9] Lipoprotein(a) and lipoprotein profile in healthy centenarians: a reappraisal of vascular risk factors
    Baggio, G
    Donazzan, S
    Monti, D
    Mari, D
    Martini, S
    Gabelli, C
    Dalla Vestra, M
    Previato, L
    Guido, M
    Pigozzo, S
    Cortella, I
    Crepaldi, G
    Franceschi, C
    [J]. FASEB JOURNAL, 1998, 12 (06) : 433 - 437
  • [10] Quantitative and qualitative alterations of acute-phase protein in healthy elderly persons
    Ballou, SP
    Lozanski, GB
    Hodder, S
    Rzewnicki, DL
    Mion, LC
    Sipe, JD
    Ford, AB
    Kushner, I
    [J]. AGE AND AGEING, 1996, 25 (03) : 224 - 230
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