The effects of acid on bone

被引：98
作者：
Bushinsky, DA [1 ]
Frick, KK [1 ]
机构：
[1] Univ Rochester, Sch Med, Dept Med, Nephrol Unit, Rochester, NY 14642 USA
来源：
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2000年 / 9卷 / 04期
关键词：
D O I：
10.1097/00041552-200007000-00008
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Metabolic acidosis induces calcium efflux from bone and in the process buffers the additional hydrogen ions. Initially metabolic acidosis stimulates physicochemical mineral dissolution and then cell-mediated bone resorption. Acidosis increases activity of the bone resorbing cells, the osteoclasts, and decreases activity of the bone forming cells, the osteoblasts, Osteoblastic immediate early response genes are inhibited as are genes controlling matrix formation. Curr Opin Nephrol Hypertens 9:369-379. (C) 2000 Lippincott Williams & Wilkins.
引用
收藏
页码：369 / 379
页数：11
相关论文
共 117 条
12345678910