Dermatologic and Dermatopathologic Features of Monogenic Autoinflammatory Diseases

被引：27

作者：

Figueras-Nart, Ignasi ^{[1
]}

Mascaro, Jose M., Jr. ^{[2
]}

Solanich, Xavier ^{[3
]}

Hernandez-Rodriguez, Jose ^{[4
]}

机构：

[1] Univ Barcelona, Bellvitge Hosp, Dept Dermatol, Barcelona, Spain

[2] Univ Barcelona, IDIBAPS, Hosp Clin, Dept Dermatol, Barcelona, Spain

[3] Univ Barcelona, Bellvitge Hosp, Dept Internal Med, Barcelona, Spain

[4] Univ Barcelona, Clin Unit, Autoinflammatory Dis & Vasculitis Res Unit, Dept Autoimmune Dis,Hosp Clin,IDIBAPS, Barcelona, Spain

来源：

FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷

关键词：

monogenic autoinflammatory diseases; autoinflammatory diseases; clinical dermatology; maculopapular rash; urticarial rash; dermatopathology; classification; RECURRENT MULTIFOCAL OSTEOMYELITIS; FAMILIAL MEDITERRANEAN FEVER; AICARDI-GOUTIERES SYNDROME; INTERLEUKIN-36-RECEPTOR ANTAGONIST DEFICIENCY; CONGENITAL DYSERYTHROPOIETIC ANEMIA; GENERALIZED PUSTULAR PSORIASIS; ERYSIPELAS-LIKE ERYTHEMA; OF-FUNCTION MUTATIONS; PERIODIC FEVER; PYODERMA-GANGRENOSUM;

D O I：

10.3389/fimmu.2019.02448

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoinflammatory diseases include disorders with a monogenic cause and also complex conditions associated to polygenic or multifactorial factors. An increased number of both monogenic and polygenic autoinflammatory conditions have been identified during the last years. Although skin manifestations are often predominant in monogenic autoinflammatory diseases, clinical and histopathological information regarding their dermatological involvement is still scarce. Monogenic autoinflammatory diseases with cutaneous expression can be classified based on the predominant lesion: (1) maculopapular rashes or inflammatory plaques; (2) urticarial rashes; (3) pustular, pyogenic or neutrophilic dermatosis-like rashes; (4) panniculitis or subcutaneous nodules; (5) vasculitis or vasculopathy; (6) hyperkeratotic lesions; (7) hyperpigmented lesions; (8) bullous lesions; and (9) aphthous lesions. By using this classification, this review intends to provide clinical and histopathological knowledge about cutaneous involvement in monogenic autoinflammatory diseases.

引用

页数：25

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