Neurotrophic effects of bone morphogenetic protein-7 in a rat model of Parkinson's disease

被引：30

作者：

Harvey, BK ^{[1
]}

Mark, A ^{[1
]}

Chou, J ^{[1
]}

Chen, GJ ^{[1
]}

Hoffer, BJ ^{[1
]}

Wang, Y ^{[1
]}

机构：

[1] Natl Inst Drug Abuse, Neural Protect & Regenerat Sect, NIH, Baltimore, MD 21224 USA

来源：

BRAIN RESEARCH | 2004年 / 1022卷 / 1-2期

关键词：

bone morphogenetic protein-7; Parkinson's disease; neuroprotection;

D O I：

10.1016/j.brainres.2004.06.072

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies have demonstrated that pretreatment with bone morphogenetic protein-7 (BMP7) reduces ischemic neuronal injury in vivo. Moreover, exogenous application of BMP7 increases both the number of tyrosine hydroxylase (+) cells and dopamine (DA) uptake in rat mesencephalic cell cultures. The purpose of this study was to investigate the in vivo effects of BMP7 on 6-hydroxydopamine (6-OHDA) induced lesioning of midbrain DA neurons. Adult Fischer 344 rats were anesthetized and injected with BMP7 or vehicle into the left substantia nigra, followed by local administration of 9 mug of 6-OHDA into the left medial forebrain bundle. The lesioned animals that received BMP7 pretreatment, as compared to vehicle/6-OHDA controls, had a significant reduction in methamphetamine-induced rotation 1 month after the surgery. BMP7-pretreatment partially preserved KCl-induced dopamine release in the lesioned striatum and significantly increased TH immunoreactivity in the lesioned nigra and striatum. In summary, our data suggest that BMP7 has neuroprotective and/or neuroreparative effects against 6-OHDA lesioning of the nigrostriatal DA pathway in an animal model of Parkinson's disease (PD). Published by Elsevier B.V.

引用

页码：88 / 95

页数：8

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