Hydroxoiridium-Catalyzed Hydroalkylation of Terminal Alkenes with Ureas by C(sp3)-H Bond Activation

被引：39

作者：

Yamauchi, Daisuke ^{[1
]}

Nishimura, Takahiro ^{[1
]}

Yorimitsu, Hideki ^{[1
]}

机构：

[1] Kyoto Univ, Dept Chem, Grad Sch Sci, Sakyo Ku, Kyoto 6068502, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 25期

关键词：

alkenes; C-H activation; iridium; reaction mechanisms; synthetic methods; C-H BOND; LIGHT PHOTOREDOX CATALYSIS; ALPHA-AMINOALKYL RADICALS; CYCLIC AMINES; NITROGEN ATOM; FUNCTIONALIZATION REACTIONS; ORGANIC-SYNTHESIS; COUPLING REACTION; DIRECTING GROUPS; VINYL ETHERS;

D O I：

10.1002/anie.201702169

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Direct alkylation of a methyl group, on di- and trisubstituted ureas, with terminal alkenes by C(sp(3))-H bond activation proceeded in the presence of a hydroxoiridium/bisphosphine catalyst to give high yields of the corresponding addition products. The hydroxoiridium/bisphosphine complex generates an amidoiridium intermediate by reaction with ureas having an N-H bond.

引用

页码：7200 / 7204

页数：5

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