Hydroxoiridium-Catalyzed Hydroalkylation of Terminal Alkenes with Ureas by C(sp3)-H Bond Activation

被引：39
|
作者：
Yamauchi, Daisuke [1 ]
Nishimura, Takahiro [1 ]
Yorimitsu, Hideki [1 ]
机构：
[1] Kyoto Univ, Dept Chem, Grad Sch Sci, Sakyo Ku, Kyoto 6068502, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 25期
关键词：
alkenes; C-H activation; iridium; reaction mechanisms; synthetic methods; C-H BOND; LIGHT PHOTOREDOX CATALYSIS; ALPHA-AMINOALKYL RADICALS; CYCLIC AMINES; NITROGEN ATOM; FUNCTIONALIZATION REACTIONS; ORGANIC-SYNTHESIS; COUPLING REACTION; DIRECTING GROUPS; VINYL ETHERS;
D O I：
10.1002/anie.201702169
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Direct alkylation of a methyl group, on di- and trisubstituted ureas, with terminal alkenes by C(sp(3))-H bond activation proceeded in the presence of a hydroxoiridium/bisphosphine catalyst to give high yields of the corresponding addition products. The hydroxoiridium/bisphosphine complex generates an amidoiridium intermediate by reaction with ureas having an N-H bond.
引用
收藏
页码：7200 / 7204
页数：5
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