Translational alterations in pancreatic cancer: a central role for the integrated stress response

被引：9

作者：

Shin, Sauyeun ^{[1
,2
]}

Solorzano, Jacobo ^{[1
,2
]}

Liauzun, Mehdi ^{[1
,2
]}

Pyronnet, Stephane ^{[1
,2
]}

Bousquet, Corinne ^{[1
,2
]}

Martineau, Yvan ^{[1
,2
]}

机构：

[1] Univ Toulouse III Paul Sabatier, CNRS, Ctr Rech Cancerol Toulouse CRCT, INSERM U1037,ERL5294, Toulouse, France

[2] Equipe Labellisee Ligue Canc, Villejuif, France

来源：

NAR CANCER | 2022年 / 4卷 / 04期

关键词：

ENDOPLASMIC-RETICULUM STRESS; MESSENGER-RNA TRANSLATION; INITIATION-FACTOR; 3F; PROTEIN-SYNTHESIS; CELL PLASTICITY; ONCOGENIC KRAS; EIF4E; PHOSPHORYLATION; INHIBITOR; KINASE;

D O I：

10.1093/narcan/zcac031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

mRNA translation is a key mechanism for cancer cell proliferation and stress adaptation. Regulation of this machinery implicates upstream pathways such as PI3K/AKT/mTOR, RAS/MEK/ERK and the integrated stress response (ISR), principally coordinating the translation initiation step. During the last decade, dysregulation of the mRNA translation process in pancreatic cancer has been widely reported, and shown to critically impact on cancer initiation, development and survival. This includes translation dysregulation of mRNAs encoding oncogenes and tumor suppressors. Hence, cancer cells survive a stressful microenvironment through a flexible regulation of translation initiation for rapid adaptation. The ISR pathway has an important role in chemoresistance and shows high potential therapeutic interest. Despite the numerous translational alterations reported in pancreatic cancer, their consequences are greatly underestimated. In this review, we summarize the different translation dysregulations described in pancreatic cancer, which make it invulnerable, as well as the latest drug discoveries bringing a glimmer of hope.

引用

页数：13

共 124 条

[81] Anti-metastatic potential of somatostatin analog SOM230: Indirect pharmacological targeting of pancreatic cancerassociated fibroblasts [J].

Moatassim-Billah, Siham ;

Duluc, Camille ;

Samain, Remi ;

Jean, Christine ;

Perraud, Aurelie ;

Decaup, Emilie ;

Cassant-Sourdy, Stephanie ;

Bakri, Youssef ;

Selves, Janick ;

Schmid, Herbert ;

Martineau, Yvan ;

Mathonnet, Muriel ;

Pyronnet, Stephane ;

Bousquet, Corinne .

ONCOTARGET, 2016, 7 (27) :41584-41598

[82] Deciphering the complex interplay between pancreatic cancer, diabetes mellitus subtypes and obesity/BMI through causal inference and mediation analyses [J].

Molina-Montes, Esther ;

Coscia, Claudia ;

Gomez-Rubio, Paulina ;

Fernandez, Alba ;

Boenink, Rianne ;

Rava, Marta ;

Marquez, Mirari ;

Molero, Xavier ;

Lohr, Matthias ;

Sharp, Linda ;

Michalski, Christoph W. ;

Farre, Antoni ;

Perea, Jose ;

O'Rorke, Michael ;

Greenhalf, William ;

Iglesias, Mar ;

Tardon, Adonina ;

Gress, Thomas M. ;

Barbera, Victor M. ;

Crnogorac-Jurcevic, Tatjana ;

Munoz-Bellvis, Luis ;

Enrique Dominguez-Munoz, J. ;

Renz, Harald ;

Balcells, Joaquim ;

Costello, Eithne ;

Ilzarbe, Lucas ;

Kleeff, Jorg ;

Kong, Bo ;

Mora, Josefina ;

O'Driscoll, Damian ;

Poves, Ignasi ;

Scarpa, Aldo ;

Yu, Jingru ;

Hidalgo, Manuel ;

Lawlor, Rita T. ;

Ye, Weimin ;

Carrato, Alfredo ;

Real, Francisco X. ;

Malats, Nuria .

GUT, 2021, 70 (02) :319-329

[83] Targeting mTOR dependency in pancreatic cancer [J].

Morran, Douglas C. ;

Wu, Jianmin ;

Jamieson, Nigel B. ;

Mrowinska, Agata ;

Kalna, Gabriela ;

Karim, Saadia A. ;

Au, Amy Y. M. ;

Scarlett, Christopher J. ;

Chang, David K. ;

Pajak, Malgorzata Z. ;

Oien, Karin A. ;

McKay, Colin J. ;

Carter, C. Ross ;

Gillen, Gerry ;

Champion, Sue ;

Pimlott, Sally L. ;

Anderson, Kurt I. ;

Evans, T. R. Jeffry ;

Grimmond, Sean M. ;

Biankin, Andrew V. ;

Sansom, Owen J. ;

Morton, Jennifer P. .

GUT, 2014, 63 (09) :1481-1489

[84] 4E-BP restrains eIF4E phosphorylation [J].

Mueller, David ;

Lasfargues, Charline ;

El Khawand, Sally ;

Alard, Amandine ;

Schneider, Robert J. ;

Bousquet, Corinne ;

Pyronnet, Stephane ;

Martineau, Yvan .

TRANSLATION, 2013, 1 (02)

[85] eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss i n pancreatic cancer [J].

Muller, David ;

Shin, Sauyeun ;

de Rugy, Theo Goullet ;

Samain, Remi ;

Baer, Romain ;

Strehaiano, Manon ;

Masvidal-Sanz, Laia ;

Guillermet-Guibert, Julie ;

Jean, Christine ;

Tsukumo, Yoshinori ;

Sonenberg, Nahum ;

Marion, Frederic ;

Guilbaud, Nicolas ;

Hoffmann, Jean-Sebastien ;

Larsson, Ola ;

Bousquet, Corinne ;

Pyronnet, Stephane ;

Martineau, Yvan .

JCI INSIGHT, 2019, 4 (21)

[86] Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response [J].

Nakamura, Akito ;

Nambu, Tadahiro ;

Ebara, Shunsuke ;

Hasegawa, Yuka ;

Toyoshima, Kosei ;

Tsuchiya, Yasuko ;

Tomita, Daisuke ;

Fujimoto, Jun ;

Kurasawa, Osamu ;

Takahara, Chisato ;

Ando, Ayumi ;

Nishigaki, Ryuichi ;

Satomi, Yoshinori ;

Hata, Akito ;

Hara, Takahito .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (33) :E7776-E7785

[87] Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis [J].

Nawrocki, ST ;

Carew, JS ;

Pino, MS ;

Highshaw, RA ;

Dunner, K ;

Huang, P ;

Abbruzzese, JL ;

McConkey, DJ .

CANCER RESEARCH, 2005, 65 (24) :11658-11666

[88] One-carbon metabolism in cancer [J].

Newman, Alice C. ;

Maddocks, Oliver D. K. .

BRITISH JOURNAL OF CANCER, 2017, 116 (12) :1499-1504

[89] Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer [J].

Niu, Zheyu ;

Wang, Mengyi ;

Zhou, Li ;

Yao, Lutian ;

Liao, Quan ;

Zhao, Yupei .

SCIENTIFIC REPORTS, 2015, 5

[90] Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer [J].

Olive, Kenneth P. ;

Jacobetz, Michael A. ;

Davidson, Christian J. ;

Gopinathan, Aarthi ;

McIntyre, Dominick ;

Honess, Davina ;

Madhu, Basetti ;

Goldgraben, Mae A. ;

Caldwell, Meredith E. ;

Allard, David ;

Frese, Kristopher K. ;

DeNicola, Gina ;

Feig, Christine ;

Combs, Chelsea ;

Winter, Stephen P. ;

Ireland-Zecchini, Heather ;

Reichelt, Stefanie ;

Howat, William J. ;

Chang, Alex ;

Dhara, Mousumi ;

Wang, Lifu ;

Rueckert, Felix ;

Gruetzmann, Robert ;

Pilarsky, Christian ;

Izeradjene, Kamel ;

Hingorani, Sunil R. ;

Huang, Pearl ;

Davies, Susan E. ;

Plunkett, William ;

Egorin, Merrill ;

Hruban, Ralph H. ;

Whitebread, Nigel ;

McGovern, Karen ;

Adams, Julian ;

Iacobuzio-Donahue, Christine ;

Griffiths, John ;

Tuveson, David A. .

SCIENCE, 2009, 324 (5933) :1457-1461

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