Role of apoptosis in the Post-traumatic stress disorder model-single prolonged stressed rats

被引:24
|
作者
Jia, Yunbo [1 ]
Han, Yunhe [1 ]
Wang, Xinyue [1 ]
Han, Fang [1 ]
机构
[1] China Med Univ, Basic Med Univ, Dept Histol & Embryol, PTSD Lab, Shenyang 110122, Liaoning, Peoples R China
关键词
Post-traumatic stress disorder; Apoptosis; The hippocampus; The amygdala; Endoplasmic reticulum; ENDOPLASMIC-RETICULUM STRESS; MEDIAL PREFRONTAL CORTEX; UNFOLDED-PROTEIN RESPONSE; DORSAL RAPHE NUCLEUS; PERK-EIF2-ALPHA SIGNALING PATHWAY; EXTINCTION RETENTION DEFICITS; PROGRAMMED CELL-DEATH; QUALITY-CONTROL; MESSENGER-RNA; ER STRESS;
D O I
10.1016/j.psyneuen.2018.05.015
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Post-traumatic stress disorder (PTSD) is a stress-related mental disorder which occurs following exposure to traumatic events. A number of brain neuroimaging studies have revealed that PTSD patients have reduced volume and abnormal functions in the hippocampus and the amygdala. However, the pathogenesis of abnormalities in certain brain regions, as induced by PTSD, remains unclear. Recent studies, using the single prolonged stress (SPS) model, an animal model of PTSD, have found that abnormal apoptosis in certain brain regions, including the hippocampus, the amygdala, and the medial prefrontal cortex (mPFC); these areas are closely associated with emotion and cognition. In this review, we summarize the mechanism of apoptosis in SPS rats, including the endoplasmic reticulum (ER) and the mitochondria pathways. For the ER pathway, three individual pathways: PERK, IRE1, and ATF6 showed different roles on apoptosis and neuroprotection. Three key factors are thought to be involved in the mitochondrial pathway and PTSD-induced apoptosis: corticosteroid receptors, apoptosis-related factors, and anti-apoptosis factors. We have investigated the role of these factors and have attempted to identify which factors of the pathways are more focused towards neuronal protection, and which are more direct towards apoptosis. We also discussed the role of autophagy and the specific differences between autophagy and apoptosis in SPS rats. Finally, we discussed emerging researches related to anti-apoptosis treatment, including PERK inhibitors, IRE1 inhibitors, and metformin; collectively, these were exciting, but limited, This review provides a summary of the current understanding of apoptosis in SPS rats and the potential anti-apoptosis treatment strategies for PTSD.
引用
收藏
页码:97 / 105
页数:9
相关论文
共 50 条
  • [21] Single-Prolonged Stress Induces Apoptosis by Activating Cytochrome C/Caspase-9 Pathway in a Rat Model of Post-traumatic Stress Disorder
    Xiao, Bing
    Yu, Bo
    Wang, Hai-tao
    Han, Fang
    Shi, Yu-xiu
    CELLULAR AND MOLECULAR NEUROBIOLOGY, 2011, 31 (01) : 37 - 43
  • [22] Behavioral changes over time in post-traumatic stress disorder: Insights from a rat model of single prolonged stress
    Wu, Zhuoyun
    Tian, Qing
    Li, Feng
    Gao, Junqiao
    Liu, Yan
    Mao, Meng
    Liu, Jing
    Wang, Shuyan
    Li, Genmao
    Ge, Dongyu
    Mao, Yingqiu
    Zhang, Wei
    Liu, Zhaolan
    Song, Yuehan
    BEHAVIOURAL PROCESSES, 2016, 124 : 123 - 129
  • [23] Post-traumatic stress disorder after prolonged mechanical ventilation
    Masseret, E.
    Bauerheim, N.
    El Hage, W.
    Mercier, E.
    Guillon, A.
    Dequin, P. -F.
    REANIMATION, 2013, 22 (01): : 80 - 89
  • [24] The metacognitive model of post-traumatic stress disorder and metacognitive therapy for post-traumatic stress disorder: A systematic review
    Brown, Renee L.
    Wood, Andrew
    Carter, Janet D.
    Kannis-Dymand, Lee
    CLINICAL PSYCHOLOGY & PSYCHOTHERAPY, 2022, 29 (01) : 131 - 146
  • [25] A mouse model of post-traumatic stress disorder
    Siegmund, A
    Wotjak, CT
    BEHAVIOURAL PHARMACOLOGY, 2005, 16 : S88 - S89
  • [26] An integrated model of post-traumatic stress disorder
    Mihaescu, G
    Baettig, D
    EUROPEAN JOURNAL OF PSYCHIATRY, 1996, 10 (04): : 233 - 242
  • [27] Activity of the Hypothalamo-Hypophyseal-Adrenocortical System in Prenatally Stressed Female Rats in a Model of Post-Traumatic Stress Disorder
    Ordyan N.E.
    Pivina S.G.
    Mironova V.I.
    Rakitskaya V.V.
    Akulova V.K.
    Neuroscience and Behavioral Physiology, 2016, 46 (5) : 552 - 558
  • [28] Formation of an anxious-depressive state in an experimental model of post-traumatic stress disorder in prenatally stressed female rats
    Ordyan N.E.
    Pivina S.G.
    Fedotova Y.O.
    Rakitskaya V.V.
    Neuroscience and Behavioral Physiology, 2013, 43 (6) : 712 - 717
  • [29] Activity of the Hypothalamic–Pituitary–Adrenal System in Prenatally Stressed Male Rats on the Experimental Model of Post-Traumatic Stress Disorder
    S. G. Pivina
    V. V. Rakitskaya
    V. K. Akulova
    N. E. Ordyan
    Bulletin of Experimental Biology and Medicine, 2016, 160 : 601 - 604
  • [30] The phenomenology of nightmares in post-traumatic stress disorder and complex post-traumatic stress disorder
    Simos, Alyssia
    Berle, David
    EUROPEAN JOURNAL OF TRAUMA & DISSOCIATION, 2023, 7 (03)