Central Motor Conduction Time and Diffusion Tensor Imaging metrics in children with complex motor disorders

Objectives: To explore potential correlations between Diffusion Tensor Imaging (DTI) metrics and Central Motor Conduction Time (CMCT) in a cohort of children with complex motor disorders. Methods: For a group of 49 children undergoing assessment for potential Deep Brain Stimulation (DBS) surgery, CMCT was derived from the latency of MEPs invoked by transcranial magnetic stimulation of the contralateral motor cortex and from peripheral conduction times. Tract-Based Spatial Statistics (TBSS) was used to compare Diffusion Tensor Imaging (DTI) metrics between children with normal and abnormal CMCT. TBSS was also used to look for correlations between these metrics and CMCT across the group. Results: Median age at assessment was 9 years (range 3-19 years). For 14/49 children a diagnosis of primary dystonia had been made. No correlation could be found between DTI metrics and CMCT, with no difference in metrics found between children with normal and abnormal CMCT. Conclusions: DTI metrics did not differ between children with normal and abnormal CMCT. Tissue properties determining CMCT may not be explained by existing DTI metrics. Significance: DTI and CMCT measurements provide complementary information for the clinical assessment of children with complex motor disorders. (C) 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.