Impact of AJCC 8th edition staging system and definitive treatment choice on the prognosis of complete responders with p16+and p16-oropharyngeal squamous cell carcinomas

被引：3
作者：
Muller, R. Grant [1 ]
Hamill, Chelsea S. [1 ]
Vu, Brandon [2 ]
Thuener, Jason [1 ,2 ]
Wasman, Jay [2 ,3 ]
Li, Shawn [1 ,2 ]
Fowler, Nicole [1 ,2 ]
Rezaee, Rod [1 ,2 ]
Lavertu, Pierre [1 ,2 ]
Yao, Min [2 ,4 ]
Burkitt, Kyunghee [2 ,5 ]
Dorth, Jennifer [2 ,4 ]
Teknos, Theodoros N. [1 ,2 ,6 ]
Pan, Quintin [1 ,2 ,6 ,7 ]
O'Neill, W. Quinn [1 ,2 ,7 ]
机构：
[1] Case Western Reserve Univ Sch Med, Univ Hosp Cleveland Med Ctr, Dept Otolaryngol Head & Neck Surg, Cleveland Hts, OH 44106 USA
[2] Univ Hosp Seidman Canc Ctr, Cleveland Hts, OH 44106 USA
[3] Case Western Reserve Univ Sch Med, Univ Hosp Cleveland Med Ctr, Dept Pathol, Cleveland Hts, OH 44106 USA
[4] Case Western Reserve Univ Sch Med, Univ Hosp Cleveland Med Ctr, Dept Radiat Oncol, Cleveland Hts, OH 44106 USA
[5] Case Western Reserve Univ Sch Med, Univ Hosp Cleveland Med Ctr, Dept Med, Div Hematol & Oncol, Cleveland Hts, OH 44106 USA
[6] Case Western Reserve Univ Sch Med, Case Comprehens Canc Ctr, Cleveland Hts, OH 44106 USA
[7] Univ Hosp Seidman Canc Ctr, 11100 Euclid Ave, Cleveland Hts, OH 44106 USA
来源：
ORAL ONCOLOGY | 2022年 / 128卷
基金：
美国国家卫生研究院;
关键词：
head and neck cancer; oropharyngeal squamous cell carcinoma; AJCC staging; human papillomavirus; p16; complete response; CANCER-PATIENTS; OROPHARYNGEAL; SURVIVAL; HEAD; RADIOTHERAPY; MANAGEMENT; SURGERY; RISK;
D O I：
10.1016/j.oraloncology.2022.105861
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objectives: To identify predictors of overall survival (OS) in oropharyngeal squamous cell carcinoma (OPSCC) patients who achieved complete response (CR). Methods: We performed a retrospective study of OPSCC patients who achieved CR from a single academic medical center. Associations between OS, AJCC 8th edition staging system, definitive treatment choice, smoking history, and p16 status were assessed. Results: p16+ status was associated with favorable prognosis for CR (p < 0.001) but not non-CR (p = 0.67) patients. For early stage, p16+ OPSCC patients who achieved CR, surgery + adjuvant radiation (RT) treatment was more durable compared to concurrent chemoradiation (CRT), particularly in smokers. Conclusions: Curative intent treatment choice and smoking history has an impact on the long-term OS of the CR p16+ OPSCC cohort. Prospective studies to define the optimal multi-modality treatment option to manage p16+ OPSCC patients is needed.
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页数：7
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