Association of Fcγ receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais

被引：131
作者：
Siriboonrit, U
Tsuchiya, N [1 ]
Sirikong, M
Kyogoku, C
Bejrachandra, S
Suthipinittharm, P
Luangtrakool, K
Srinak, D
Thongpradit, R
Fujiwara, K
Chandanayingyong, D
Tokunaga, K
机构：
[1] Univ Tokyo, Dept Human Genet, Grad Sch Med, Tokyo, Japan
[2] Mahidol Univ, Dept Transfus Med, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand
[3] Mahidol Univ, Dept Dermatol, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand
[4] Red Cross Tokyo, Dept Lab, Ctr Blood, Tokyo, Japan
来源：
TISSUE ANTIGENS | 2003年 / 61卷 / 05期
关键词：
Fc gamma RIIa; Fc gamma RIIb; Fc gamma RIIIa; Fc gamma RIIIb; HNA-1; polymorphism; susceptibility; systemic lupus erythematosus; Thais;
D O I：
10.1034/j.1399-0039.2003.00047.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We recently reported association of a newly identified polymorphism of Fcgamma receptor (FcgammaR) IIb, I232T, with systemic lupus erythematosus (SLE) in Japanese. To date, information on FcgammaR genotypes and their association with SLE is limited in South-east Asian populations. To gain further insight into the role of FcgammaR polymorphisms in the genetic predisposition of SLE, association of FcgammaRIIa-H131R, IIb-I232T, IIIa-F176V and IIIb-NA1/NA2 (HNA-1a/1b) polymorphisms with SLE was analyzed in the Thai population, using case-control association analysis. FcgammaRIIb-232T/T and IIIb-NA2/NA2 genotypes were associated with SLE with the odds ratio of 2.55. Genotype relative risk analysis revealed significant association of IIb-232T/T and IIIb-NA2/NA2, and a tendency of association of the IIIa-176F/F genotype. Moreover, carriers of FcgammaRIIa-131R were significantly increased in patients with lupus nephritis. Significant linkage disequilibrium was present among FcgammaRIIb, IIIa and IIIb, and two-locus analyses suggested that the tendency of association of FcgammaRIIIa could derive from linkage disequilibrium with IIb and IIIb. These results provided evidence that FcgammaR polymorphisms may be an important predisposing factor also in Thais in a complex manner.
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页码：374 / 383
页数：10
相关论文
共 61 条
[1]  
Amoura Z, 2000, ARTHRITIS RHEUM-US, V43, P76, DOI 10.1002/1529-0131(200001)43:1<76::AID-ANR10>3.0.CO
[2]  
2-I
[3]   Spontaneous autoimmune disease in FcγRIIB-deficient mice results from strain-specific epistasis [J].
Bolland, S ;
Ravetch, JV .
IMMUNITY, 2000, 13 (02) :277-285
[4]   Fc gamma RIIa polymorphism in systemic lupus erythematosus (SLE): No association with disease [J].
Bottto, M ;
Theodoridis, E ;
Thompson, EM ;
Beynon, HLC ;
Briggs, D ;
Isenberg, DA ;
Walport, MJ ;
Davies, KA .
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1996, 104 (02) :264-268
[5]   Nomenclature of granulocyte alloantigens [J].
Bux, J .
TRANSFUSION, 1999, 39 (06) :662-663
[6]   Characterization of a new alloantigen (SH) on the human neutrophil Fc gamma receptor IIIb [J].
Bux, J ;
Stein, EL ;
Bierling, P ;
Fromont, P ;
Clay, M ;
Stroncek, D ;
Santoso, S .
BLOOD, 1997, 89 (03) :1027-1034
[7]  
CHANDANAYINGYON.D, 1992, HLA 1991, V1, P681
[8]   Defective Fc-dependent processing of immune complexes in patients with systemic lupus erythematosus [J].
Davies, KA ;
Robson, MG ;
Peters, AM ;
Norsworthy, P ;
Nash, JT ;
Walport, MJ .
ARTHRITIS AND RHEUMATISM, 2002, 46 (04) :1028-1038
[9]  
deHaas M, 1996, J IMMUNOL, V156, P2948
[10]   Inflammation in autoimmunity: receptors for IgG revisited [J].
Dijstelbloem, HM ;
van de Winkel, JGJ ;
Kallenberg, CGM .
TRENDS IN IMMUNOLOGY, 2001, 22 (09) :510-516
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