The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells

被引：16

作者：

Bimonte, Sabrina ^{[1
]}

Barbieri, Antonio ^{[2
]}

Leongito, Maddalena ^{[1
]}

Palma, Giuseppe ^{[2
]}

Del Vecchio, Vitale ^{[2
]}

Falco, Michela ^{[2
]}

Palaia, Raffaele ^{[1
]}

Albino, Vittorio ^{[1
]}

Piccirillo, Mauro ^{[1
]}

Amore, Alfonso ^{[1
]}

Petrillo, Antonella ^{[3
]}

Granata, Vincenza ^{[3
]}

Izzo, Francesco ^{[1
]}

机构：

[1] Natl Canc Inst G Pascale Fdn, Hepatobiliary Unit, Div Abdominal Surg Oncol, IRCCS, I-80131 Naples, Italy

[2] Natl Canc Inst G Pascale Fdn, Anim Facil Unit, IRCCS, I-80131 Naples, Italy

[3] Natl Canc Inst G Pascale Fdn, Div Radiol, IRCCS, I-80131 Naples, Italy

来源：

STEM CELLS INTERNATIONAL | 2016年 / 2016卷

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; ACUTE MYELOID-LEUKEMIA; RNA-INTERFERENCE; NUCLEAR EXPORT; SIGNALING PATHWAY; MESSENGER-RNAS; TUMOR-GROWTH; C-MET; MICRORNAS; GEMCITABINE;

D O I：

10.1155/2016/8352684

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Pancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, is involved in the modulation of several biological activities ranging from invasion to metastases development, as well as drug resistance of pancreatic cancer. In this review, we synthesize the latest findings on the role of miRNAs in regulating different biological properties of pancreatic cancer stem cells.

引用

页数：7

共 102 条

[1] The Notch Pathway Is Important in Maintaining the Cancer Stem Cell Population in Pancreatic Cancer [J].

Abel, Ethan V. ;

Kim, Edward J. ;

Wu, Jingjiang ;

Hynes, Mark ;

Bednar, Filip ;

Proctor, Erica ;

Wang, Lidong ;

Dziubinski, Michele L. ;

Simeone, Diane M. .

PLOS ONE, 2014, 9 (03)

[2] Biology and Clinical Applications of Pancreatic Cancer Stem Cells [J].

Abel, Ethan V. ;

Simeone, Diane M. .

GASTROENTEROLOGY, 2013, 144 (06) :1241-1248

[3] miR-34: from bench to bedside [J].

Agostini, Massimiliano ;

Knight, Richard A. .

ONCOTARGET, 2014, 5 (04) :872-881

[4] A patient with confusion and dizziness [J].

Ahmed, Aiesha ;

Specht, Charles ;

Lowden, Max R. .

JOURNAL OF CLINICAL NEUROSCIENCE, 2012, 19 (09) :1281-+

[5] Tissular and soluble miRNAs for diagnostic and therapy improvement in digestive tract cancers [J].

Albulescu, Radu ;

Neagu, Monica ;

Albulescu, Lucian ;

Tanase, Cristiana .

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2011, 11 (01) :101-120

[6]

[Anonymous], LANCET

[7]

[Anonymous], GASTROENTEROLOGY

[8]

[Anonymous], EVIDENCE BASED COMPL

[9] Notch signalling controls pancreatic cell differentiation [J].

Apelqvist, Å ;

Li, H ;

Sommer, L ;

Beatus, P ;

Anderson, DJ ;

Honjo, T ;

de Angelis, MH ;

Lendahl, U ;

Edlund, H .

NATURE, 1999, 400 (6747) :877-881

[10] Metformin Inhibits Cell Proliferation, Migration and Invasion by Attenuating CSC Function Mediated by Deregulating miRNAs in Pancreatic Cancer Cells [J].

Bao, Bin ;

Wang, Zhiwei ;

Ali, Shadan ;

Ahmad, Aamir ;

Azmi, Asfar S. ;

Sarkar, Sanila H. ;

Banerjee, Sanjeev ;

Kong, Dejuan ;

Li, Yiwei ;

Thakur, Shivam ;

Sarkar, Fazlul H. .

CANCER PREVENTION RESEARCH, 2012, 5 (03) :355-364

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