Autologous T-cell activation fosters ABT-199 resistance in chronic lymphocytic leukemia: rationale for a combined therapy with SYK inhibitors and anti-CD20 monoclonal antibodies

被引：14

作者：

Enrique Elias, Esteban ^{[1
]}

Belen Almejun, Maria ^{[1
,2
]}

Colado, Ana ^{[1
]}

Cordini, Gregorio ^{[1
,3
]}

Vergara-Rubio, Maricef ^{[1
]}

Podaza, Enrique ^{[1
]}

Risnik, Denise ^{[1
,4
]}

Cabrejo, Maria ^{[5
]}

Fernandez-Grecco, Horacio ^{[5
]}

Fernando Bezares, Raimundo ^{[6
]}

del Rosario Custidiano, Maria ^{[7
]}

Cesar Sanchez-Avalos, Julio ^{[7
]}

Vicente, Angeles ^{[8
]}

Martin Garate, Gonzalo ^{[8
]}

Borge, Mercedes ^{[1
,4
]}

Giordano, Mirta ^{[1
,4
]}

Gamberale, Romina ^{[1
,4
]}

机构：

[1] ANM, CONICET, Inst Med Expt IMEX, Lab Inmunol Oncol, Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Fisiol Biol Mol & Celular, Buenos Aires, DF, Argentina

[3] Univ Buenos Aires, Hosp Clin Jose San Martin, Buenos Aires, DF, Argentina

[4] Univ Buenos Aires, Fac Med, Dept Microbiol Parasitol & Inmunol, Buenos Aires, DF, Argentina

[5] Sanatorio Municipal Dr Julio Mendez, Buenos Aires, DF, Argentina

[6] Hosp Gen Agudos Dr Teodoro Alvarez, Buenos Aires, DF, Argentina

[7] Inst Alexander Fleming, Buenos Aires, DF, Argentina

[8] Hosp Aleman, Buenos Aires, DF, Argentina

来源：

HAEMATOLOGICA | 2018年 / 103卷 / 10期

关键词：

KINASE INHIBITORS; B-CELLS; CLL; ENTOSPLETINIB; VENETOCLAX; SIGNALS; GS-9973;

D O I：

10.3324/haematol.2018.188680

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：E458 / E461

页数：4

共 15 条

[11] Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums [J].

Ravichandran, Kodi S. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (09) :1807-1817

[12] Targeting B-cell receptor signaling kinases in chronic lymphocytic leukemia: the promise of entospletinib [J].

Sharman, Jeff ;

Di Paolo, Julie .

THERAPEUTIC ADVANCES IN HEMATOLOGY, 2016, 7 (03) :157-170

[13] An open-label phase 2 trial of entospletinib (GS-9973), a selective spleen tyrosine kinase inhibitor, in chronic lymphocytic leukemia [J].

Sharman, Jeff ;

Hawkins, Michael ;

Kolibaba, Kathryn ;

Boxer, Michael ;

Klein, Leonard ;

Wu, Meihua ;

Hu, Jing ;

Abella, Steve ;

Yasenchak, Chris .

BLOOD, 2015, 125 (15) :2336-2343

[14] Resistance to ABT-199 induced by microenvironmental signals in chronic iymphocytic leukemia can be counteracted by CD20 antibodies or kinase inhibitors [J].

Thijssen, Rachel ;

Slinger, Erik ;

Weller, Katinka ;

Geest, Christian R. ;

Beaumont, Tim ;

van Oers, Marinus H. J. ;

Kater, Arnon P. ;

Eldering, Eric .

HAEMATOLOGICA, 2015, 100 (08) :E302-E306

[15] The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy [J].

Uchida, JJ ;

Hamaguchi, Y ;

Oliver, JA ;

Ravetch, JV ;

Poe, JC ;

Haas, KM ;

Tedder, TF .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 199 (12) :1659-1669

← 1 2 →