Autologous T-cell activation fosters ABT-199 resistance in chronic lymphocytic leukemia: rationale for a combined therapy with SYK inhibitors and anti-CD20 monoclonal antibodies

被引：14

作者：

Enrique Elias, Esteban ^{[1
]}

Belen Almejun, Maria ^{[1
,2
]}

Colado, Ana ^{[1
]}

Cordini, Gregorio ^{[1
,3
]}

Vergara-Rubio, Maricef ^{[1
]}

Podaza, Enrique ^{[1
]}

Risnik, Denise ^{[1
,4
]}

Cabrejo, Maria ^{[5
]}

Fernandez-Grecco, Horacio ^{[5
]}

Fernando Bezares, Raimundo ^{[6
]}

del Rosario Custidiano, Maria ^{[7
]}

Cesar Sanchez-Avalos, Julio ^{[7
]}

Vicente, Angeles ^{[8
]}

Martin Garate, Gonzalo ^{[8
]}

Borge, Mercedes ^{[1
,4
]}

Giordano, Mirta ^{[1
,4
]}

Gamberale, Romina ^{[1
,4
]}

机构：

[1] ANM, CONICET, Inst Med Expt IMEX, Lab Inmunol Oncol, Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Fisiol Biol Mol & Celular, Buenos Aires, DF, Argentina

[3] Univ Buenos Aires, Hosp Clin Jose San Martin, Buenos Aires, DF, Argentina

[4] Univ Buenos Aires, Fac Med, Dept Microbiol Parasitol & Inmunol, Buenos Aires, DF, Argentina

[5] Sanatorio Municipal Dr Julio Mendez, Buenos Aires, DF, Argentina

[6] Hosp Gen Agudos Dr Teodoro Alvarez, Buenos Aires, DF, Argentina

[7] Inst Alexander Fleming, Buenos Aires, DF, Argentina

[8] Hosp Aleman, Buenos Aires, DF, Argentina

来源：

HAEMATOLOGICA | 2018年 / 103卷 / 10期

关键词：

KINASE INHIBITORS; B-CELLS; CLL; ENTOSPLETINIB; VENETOCLAX; SIGNALS; GS-9973;

D O I：

10.3324/haematol.2018.188680

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：E458 / E461

页数：4

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