(1R,4S,5S)-5-((3-Hydroxypropyl)amino)-4-((1-methyl-1H-tetrazol-5-yl)thio)cyclopent-2-en-1-ol

被引：1

作者：

Fortunato, Milene A. G. ^{[1
]}

Siopa, Filipa ^{[1
]}

Afonso, Carlos A. M. ^{[1
]}

机构：

[1] Univ Lisbon, Res Inst Med iMed ULisboa, Fac Pharm, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal

来源：

MOLBANK | 2021年 / 2021卷 / 02期

关键词：

aminocyclopentitol; bicyclic aziridine; water chemistry; nucleophilic substitution; PYRIDINIUM SALT PHOTOCHEMISTRY; AMINOCYCLOPENTITOLS; AZIRIDINES; INHIBITOR; VERSATILE; CYP51;

D O I：

10.3390/M1199

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using environmentally friendly conditions, the nucleophilic ring-opening reaction of 6-azabicyclo[3.1.0]hex-3-en-2-ol with 1-methyl-1H-tetrazole-5-thiol provided a novel thiol-incorporated aminocyclopentitol, (1R,4S,5S)-5-((3-hydroxypropyl)amino)-4-((1-methyl-1H-tetrazol-5-yl)thio) cyclopent-2-en-1-ol, in excellent yield (95%). The newly synthesized compound was analyzed and characterized via H-1, C-13-NMR, HSQC, and mass spectral data.

引用

页数：5

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