Maternal hypothyroidism reduces the expression of the kisspeptin/ Kiss1r system in the maternal-fetal interface of rats

被引：8
作者：
Santos, Bianca Reis [1 ]
Cordeiro, Jeane Martinha dos Anjos [1 ]
Santos, Luciano Cardoso [1 ]
de Oliveira, Luciana Santos [1 ]
Mendonca, Leticia Dias [1 ]
Santos, Emilly Oliveira [1 ]
de Macedo, Isabella Oliveira [1 ]
Szawka, Raphael Escorsim [2 ]
Serakides, Rogeria [3 ]
Silva, Juneo Freitas [1 ]
机构：
[1] Univ Estadual Santa Cruz, Ctr Microscopia Eletron, Dept Ciencias Biol, Campus Soane Nazare de Andrade, BR-45662900 Ilheus, BA, Brazil
[2] Univ Fed Minas Gerais, Dept Fisiol & Biofis, Inst Ciencias Biol, BR-31270901 Belo Horizonte, MG, Brazil
[3] Univ Fed Minas Gerais, Dept Clin & Cirurgia Vet, Escola Vet, BR-31270901 Belo Horizonte, MG, Brazil
来源：
REPRODUCTIVE BIOLOGY | 2022年 / 22卷 / 02期
关键词：
Kisspeptin; Trophoblast; Thyroid; Placenta; Rat; 1ST TRIMESTER TROPHOBLAST; PLACENTAL EXPRESSION; PREGNANCY; RECEPTOR; WOMEN; PREECLAMPSIA; MIGRATION; INVASION;
D O I：
10.1016/j.repbio.2022.100615
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Alterations of circulating and placental levels of kisspeptin have been associated with gestational diseases. However, there are still no studies on the placental and decidual expression of Kiss1 and its receptor Kiss1r in maternal hypothyroidism, which is the aim of this work. We demonstrate that the fetoplacental restriction caused by hypothyroidism in rats is associated with a reduction in the Kiss1r expression and reduced Kiss1 and Kiss1r mRNA levels in the decidua and/or placenta. This demonstrate that fetoplacental restriction in hypothyroid rats is linked with a suppression of the kisspeptin/Kiss1r system at the maternal-fetal interface.(c) 2022 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier B.V. All rights reserved.
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页数：5
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