Photic stimulation-induced alteration of brain energy metabolism measured by 31P-MR spectroscopy in patients with MELAS

被引：17

作者：

Kato, T ^{[1
]}

Murashita, J

Shioiri, T

Terada, M

Inubushi, T

Kato, N

机构：

[1] Univ Tokyo, Fac Med, Dept Neuropsychiat, Tokyo 113, Japan

[2] Shiga Univ Med Sci, Dept Internal Med 3, Otsu, Shiga 52021, Japan

[3] Shiga Univ Med Sci, Mol Neurobiol Res Ctr, Otsu, Shiga 52021, Japan

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1998年 / 155卷 / 02期

关键词：

brain energy metabolism; MELAS (mitochondrial myopathy; encephalopathy; lactic acidosis; and stroke-like episodes); phosphocreatine; phosphorus-31 magnetic resonance spectroscopy (P-31-MRS); 3243 mitochondrial DNA mutation;

D O I：

10.1016/S0022-510X(97)00308-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We examined brain energy metabolism by phosphorus-31 magnetic resonance spectroscopy (P-31-MRS) in the occipital cortex in a mother and a daughter with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) during photic stimulation. The peak area ratio of phosphocreatine markedly decreased during photic stimulation, and subsequently increased after the stimulation. This method, photic stimulation-P-31-MRS, may be useful in assessing brain energy metabolism in neurological diseases. (C) 1998 Elsevier Science B.V.

引用

页码：182 / 185

页数：4