New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch

被引：2
作者：
Lu, Qing-Yun [1 ,5 ]
Zhang, Jia-Hui [1 ,2 ]
Li, Ying-Yao [1 ,3 ]
Pu, Xue-Xue [1 ,4 ]
Zhang, Cui-Shan [1 ,5 ]
Liu, Shuai [1 ,5 ]
Wan, Jia-Jia [1 ,5 ]
Di, Ying-Tong [1 ]
Hao, Xiao-Jiang [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
[2] Southwest Univ, Sch Life Sci, Chongqing 400715, Peoples R China
[3] Yunnan Univ, Kunming, Yunnan, Peoples R China
[4] Yunnan Univ Tradit Chinese Med, Kunming, Yunnan, Peoples R China
[5] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
NATURAL PRODUCTS AND BIOPROSPECTING | 2021年 / 11卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Daphniphyllum angustifolium hutch; Secodaphnane-type; Daphnioldhanol A; Cytotoxic activity; CHEMISTRY; SKELETON;
D O I：
10.1007/s13659-021-00309-w
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
One new Daphniphyllum alkaloid, daphnioldhanol A (1), together with three known ones, were isolated from the stem part of Daphniphyllum angustifolium Hutch. Their structures were elucidated by spectroscopic methods and comparing with the literature data. Compound 2 is a new natural product, but known by synthesis as a racemate. Compound 1 exhibited week cytotoxic activity against Hela cell line with IC50 of 31.9 mu M.
引用
收藏
页码：453 / 457
页数：5
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