Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression

被引：24

作者：

Gomez de Barreda, Elena ^{[1
]}

Dawson, Hana N. ^{[2
]}

Vitek, Michel P. ^{[2
]}

Avila, Jesus ^{[1
,3
]}

机构：

[1] Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain

[2] Duke Univ, Div Neurol, Durham, NC 27710 USA

[3] CIBERNED, Madrid 28031, Spain

来源：

FEBS LETTERS | 2010年 / 584卷 / 11期

关键词：

Neuron maturation; Tau k.o; Nuclear tau; BAF-57; Gene expression; Axonogenesis; HIPPOCAMPAL-NEURONS; NUCLEAR-TAU; CELL-CULTURE; SNF COMPLEX; MICROTUBULE; BINDING; DNA; MICE; REST; IDENTIFICATION;

D O I：

10.1016/j.febslet.2010.03.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although tau is mainly located in the cell cytoplasm, mostly bound to tubulin, it may also be found in the nucleus of neurons. Hence, we tested whether tau might play a role in regulating the expression of certain genes by comparing gene expression in mice containing or lacking the tau protein. Our results identified a significant difference in the expression of the smarce1 gene, which codes for the BAF-57 protein, a protein involved in the repression of neuron specific genes. These data suggest a role for tau in neuron maturation. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：2265 / 2270

页数：6

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