Skeletal muscle metabolic changes in peripheral arterial disease contribute to exercise intolerance: a point-counterpoint discussion

被引：57

作者：

Brass, EP

Hiatt, WR

Green, S

机构：

[1] Harbor UCLA Med Ctr, Dept Med, Ctr Clin Pharmacol, Torrance, CA 90509 USA

[2] Colorado Prevent Ctr, Denver, CO 80203 USA

[3] Univ Colorado, Hlth Sci Ctr, Dept Med, Div Geriatr,Sect Vasc Med, Denver, CO 80202 USA

[4] Univ Colorado, Hlth Sci Ctr, Dept Med, Sect Vasc Med,Div Cardiol, Denver, CO 80202 USA

[5] Univ New England, Sch Biol Biomed & Mol Sci, Armidale, NSW, Australia

来源：

VASCULAR MEDICINE | 2004年 / 9卷 / 04期

关键词：

blood flow; intermittent claudication; muscle metabolism; peripheral vascular disease;

D O I：

10.1191/1358863x04vm572ra

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Patients with claudication have a marked impairment in exercise performance. Several factors contribute to this limitation, including reductions in large vessel blood flow and oxygen delivery as well as metabolic abnormalities in skeletal muscle. The relative contribution of these factors and their role in the pathophysiology of the exercise limitation is discussed using a point-counterpoint approach. Future directions for research conclude the discussion.

引用

页码：293 / 301

页数：9

共 83 条

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