Ponesimod modulates the Th1/Th17/Treg cell balance and ameliorates disease in experimental autoimmune encephalomyelitis

被引：16

作者：

Hou, Huiqing ^{[1
]}

Sun, Yafei ^{[1
]}

Miao, Jun ^{[2
]}

Gao, Mengying ^{[3
]}

Guo, Li ^{[1
]}

Song, Xiujuan ^{[1
]}

机构：

[1] Hebei Med Univ, Dept Neurol, Key Lab Hebei Neurol, Hosp 2, Shijiazhuang 050000, Hebei, Peoples R China

[2] Hebei Med Univ, Dept Dermatol, North China Petr Bur Gen Hosp, Renqiu 062552, Hebei, Peoples R China

[3] Hebei Med Univ, Emergency Dept, Hosp 2, Shijiazhuang 050000, Hebei, Peoples R China

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2021年 / 356卷

基金：

中国国家自然科学基金;

关键词：

Experimental autoimmune encephalomyelitis; Multiple sclerosis; Ponesimod; Sphingosine-1-phosphate receptor; Th1; Th17; Treg; T-CELLS; DIFFERENTIATION; MODEL; TH17;

D O I：

10.1016/j.jneuroim.2021.577583

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sphingosine-1-phosphate receptor 1 (S1P1) plays an important role in autoimmune disease. Here, we evaluated whether ponesimod, an S1P1 modulator, affects inflammation in experimental autoimmune encephalomyelitis (EAE) and investigated Th1/Th2/Th17/Treg cell subsets. Ponesimod treatment ameliorated EAE and alleviated inflammatory infiltration. Compared with untreated EAE, ponesimod-treated mice had lower Th1 and Th17 cell numbers and higher Treg cell numbers; their IFN-gamma, T-bet, IL-17, and ROR gamma t levels as well as their pmTOR/mTOR ratio were diminished, while their TGF-beta and Foxp3 levels were enhanced. These results suggest that ponesimod modulates the Th1/Th17/Treg balance and regulates the mTOR pathway.

引用

页数：8

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