Copper(I) and N-fluorobenzenesulfonimide-mediated direct regioselective halogenation of 8-amidoquinolines on the C5 position

被引：37

作者：

He, Xin ^{[1
,2
]}

Xu, Yi-zhu ^{[1
]}

Kong, Ling-xuan ^{[3
]}

Wu, Huan-huan ^{[1
]}

Ji, De-zhong ^{[1
,3
]}

Wang, Zhi-bin ^{[3
]}

Xu, Yun-gen ^{[1
,3
]}

Zhu, Qi-hua ^{[1
,3
]}

机构：

[1] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China

[2] Changzhou Vocat Inst Engn, Changzhou 213164, Peoples R China

[3] China Pharmaceut Univ, Dept Med Chem, Jiangsu Key Lab Drug Design & Optimizat, Nanjing 210009, Jiangsu, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2017年 / 4卷 / 06期

关键词：

MILD CONDITIONS; H ACTIVATION; DIRECT ARYLATION; C-8; POSITION; LIVING CELLS; QUINOLINES; OXIDES; FUNCTIONALIZATION; HETEROCYCLES; BONDS;

D O I：

10.1039/c6qo00644b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and convenient method for the direct regioselective halogenation of 8-amidoquinolines has been developed. In the presence of CuX and N-fluorobenzenesulfonimide (NFSI), the C5-halogenation products of 8-acylaminoquinolines were obtained in moderate to excellent yields. This new procedure provides facile access to a variety of C5-halogenation of 8-amidoquinolines under mild conditions.

引用

页码：1046 / 1050

页数：5

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