The Role of Post-Translational Modifications in the Phase Transitions of Intrinsically Disordered Proteins

被引：133
|
作者：
Owen, Izzy [1 ]
Shewmaker, Frank [1 ]
机构：
[1] Uniformed Serv Univ Hlth Sci, Dept Biochem, Bethesda, MD 20814 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 21期
基金：
美国国家卫生研究院;
关键词：
liquid-liquid phase separation; intrinsically disordered regions; post-translational modifications; membraneless organelles; RNA-BINDING PROTEINS; PRION-LIKE DOMAINS; STRESS GRANULES; IN-VITRO; SEPARATION; PHOSPHORYLATION; FUS; AGGREGATION; SEQUENCE; TDP-43;
D O I：
10.3390/ijms20215501
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Advances in genomics and proteomics have revealed eukaryotic proteomes to be highly abundant in intrinsically disordered proteins that are susceptible to diverse post-translational modifications. Intrinsically disordered regions are critical to the liquid-liquid phase separation that facilitates specialized cellular functions. Here, we discuss how post-translational modifications of intrinsically disordered protein segments can regulate the molecular condensation of macromolecules into functional phase-separated complexes.
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页数：14
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