Immunological intervention to preserve beta-cell function in type 1 diabetes

被引：4

作者：

Schloot, N. C. ^{[1
,2
]}

机构：

[1] Univ Dusseldorf, Inst Klin Diabetol, Deutsch Diabet Zentrum, Leibniz Zentrum Diabet Forsch, D-40225 Dusseldorf, Germany

[2] Univ Klinikum Dusseldorf, Klin Stoffwechselkrankheiten, Dusseldorf, Germany

来源：

DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT | 2010年 / 135卷 / 18期

关键词：

type; 1; diabetes; beta-cell function; immunomodulation; PROTEIN PEPTIDE DIAPEP277; DOUBLE-BLIND; C-PEPTIDE; YOUNG-ADULTS; ONSET; CHILDREN; INSULIN; RISK; TRIAL; COMPLICATIONS;

D O I：

10.1055/s-0030-1253678

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 1 diabetes is a chronic immune mediated disease leading to selective loss of insulin producing ß-cells. The incidence of type 1 diabetes has been rising. In past years quite a number of studies have been performed that aim to mitigate disease progression after diagnosis (tertiary prevention), in islet-antibody positive subjects at increased diabetes risk (secondary prevention) or in subjects genetically at risk but without autoantibodies (primary prevention). Studies of tertiary prevention are based on anti-inflammatory, T-cell directed, antigen-specific or stem cell approaches. Amelioration of disease course has been seen in a few of these trials, but no therapeutic regimen has so far been developed to cure type 1 diabetes after its clinical manifestation. © 2010 Georg Thieme Verlag KG Stuttgart.

引用

页码：915 / 921

页数：7

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