Calcium in the Golgi apparatus

被引:86
作者
Missiaen, Ludwig [1 ]
Dode, Leonard [1 ]
Vanoevelen, Jo [1 ]
Raeymaekers, Luc [1 ]
Wuytack, Frank [1 ]
机构
[1] Dept Mol Cellbiol, Afdeling Fysiol, B-3000 Louvain, Belgium
关键词
Golgi apparatus; calcium; SPCA; Hailey-Hailey disease;
D O I
10.1016/j.ceca.2006.11.001
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The secretory-pathway Ca2+-ATPases (SPCAs) represent a recently recognized family of phosphorylation-type ATPases that supply the lumen of the Golgi apparatus with Ca2+ and Mn2+ needed for the normal functioning of this structure. Mutations of the human SPCA1 gene (ATP2C1) cause Hailey-Hailey disease, an amosomal dominant skin disorder in which keratinocytes in the suprabasal layer of the epidermis detach. We will first review the physiology of the SPCAs and then discuss how mutated SPCA1 proteins can lead to an epidermal disorder. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:405 / 416
页数:12
相关论文
共 114 条
[41]   The distinct roles of the N-terminal copper-binding sites in regulation of catalytic activity of the Wilson's disease protein [J].
Huster, D ;
Lutsenko, S .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (34) :32212-32218
[42]   Type 1 segmental manifestation of Hailey-Hailey disease [J].
Hwang, LY ;
Lee, JB ;
Richard, G ;
Uitto, JJ ;
Hsu, S .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2003, 49 (04) :712-714
[43]   Mutations of ATP2C1 in Japanese patients with Hailey-Hailey disease: intrafamilial and interfamilial phenotype variations and lack of correlation with mutation patterns [J].
Ikeda, S ;
Shigihara, T ;
Mayuzumi, N ;
Yu, XB ;
Ogawa, H .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2001, 117 (06) :1654-1656
[44]  
Ishikawa K, 1998, DNA Res, V5, P169, DOI 10.1093/dnares/5.3.169
[45]   DEPLETION OF MANGANESE WITHIN THE SECRETORY PATHWAY INHIBITS O-LINKED GLYCOSYLATION IN MAMMALIAN-CELLS [J].
KAUFMAN, RJ ;
SWAROOP, M ;
MURTHARIEL, P .
BIOCHEMISTRY, 1994, 33 (33) :9813-9819
[46]   Transcriptional regulation of ATP2C1 gene by Sp1 and YY1 and reduced function of its promoter in Hailey-Hailey disease keratinocytes [J].
Kawada, H ;
Nishiyama, C ;
Takagi, A ;
Tokura, T ;
Nakano, N ;
Maeda, K ;
Mayuzumi, N ;
Ikeda, S ;
Okumura, K ;
Ogawa, H .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2005, 124 (06) :1206-1214
[47]  
König A, 2000, EUR J DERMATOL, V10, P265
[48]   FAMILIAL COSEGREGATION OF AFFECTIVE-DISORDER AND HAILEY-HAILEY DISEASE [J].
KORNER, J ;
RIETSCHEL, M ;
NOTHEN, MM ;
WILK, CM ;
BAUER, R ;
PROPPING, P ;
MOLLER, HJ .
BRITISH JOURNAL OF PSYCHIATRY, 1993, 163 :109-110
[49]   Keratinocytes cultured from patients with Hailey-Hailey disease and Darier disease display distinct patterns of calcium regulation [J].
Leinonen, PT ;
Myllylä, RM ;
Hägg, PM ;
Tuukkanen, J ;
Koivunen, J ;
Peltonen, S ;
Oikarinen, A ;
Korkiamäki, T ;
Peltonen, J .
BRITISH JOURNAL OF DERMATOLOGY, 2005, 153 (01) :113-117
[50]   Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids - Implications for depletion of endoplasmic reticulum calcium stores and apoptosis in cholesterol-loaded macrophages [J].
Li, YK ;
Ge, MT ;
Ciani, L ;
Kuriakose, G ;
Westover, EJ ;
Dura, M ;
Covey, DF ;
Freed, JH ;
Maxfield, FR ;
Lytton, J ;
Tabas, I .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (35) :37030-37039