Calcium in the Golgi apparatus

被引：86
作者：
Missiaen, Ludwig [1 ]
Dode, Leonard [1 ]
Vanoevelen, Jo [1 ]
Raeymaekers, Luc [1 ]
Wuytack, Frank [1 ]
机构：
[1] Dept Mol Cellbiol, Afdeling Fysiol, B-3000 Louvain, Belgium
来源：
CELL CALCIUM | 2007年 / 41卷 / 05期
关键词：
Golgi apparatus; calcium; SPCA; Hailey-Hailey disease;
D O I：
10.1016/j.ceca.2006.11.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The secretory-pathway Ca2+-ATPases (SPCAs) represent a recently recognized family of phosphorylation-type ATPases that supply the lumen of the Golgi apparatus with Ca2+ and Mn2+ needed for the normal functioning of this structure. Mutations of the human SPCA1 gene (ATP2C1) cause Hailey-Hailey disease, an amosomal dominant skin disorder in which keratinocytes in the suprabasal layer of the epidermis detach. We will first review the physiology of the SPCAs and then discuss how mutated SPCA1 proteins can lead to an epidermal disorder. (c) 2006 Elsevier Ltd. All rights reserved.
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页码：405 / 416
页数：12
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