Dual Functions of Microglia in Ischemic Stroke

被引：405

作者：

Qin, Chuan ^{[1
]}

Zhou, Luo-Qi ^{[1
]}

Ma, Xiao-Tong ^{[1
]}

Hu, Zi-Wei ^{[1
]}

Yang, Sheng ^{[1
]}

Chen, Man ^{[1
]}

Bosco, Dale B. ^{[2
]}

Wu, Long-Jun ^{[2
]}

Tian, Dai-Shi ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Neurol, Wuhan 430030, Hubei, Peoples R China

[2] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA

来源：

NEUROSCIENCE BULLETIN | 2019年 / 35卷 / 05期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

Microglia; Inflammation; Ischemic stroke; Signaling pathways; FOCAL CEREBRAL-ISCHEMIA; TUMOR-NECROSIS-FACTOR; BLOOD-BRAIN-BARRIER; PROTON CHANNEL HV1; PHOTOTHROMBOTIC STROKE; INFLAMMATORY RESPONSE; SUBVENTRICULAR ZONE; NEUROVASCULAR UNIT; TEMPORAL PROFILE; GLUTAMATE UPTAKE;

D O I：

10.1007/s12264-019-00388-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ischemic stroke is a leading cause of morbidity and mortality worldwide. Resident microglia are the principal immune cells of the brain, and the first to respond to the pathophysiological changes induced by ischemic stroke. Traditionally, it has been thought that microglial activation is deleterious in ischemic stroke, and therapies to suppress it have been intensively explored. However, increasing evidence suggests that microglial activation is also critical for neurogenesis, angiogenesis, and synaptic remodeling, thereby promoting functional recovery after cerebral ischemia. Here, we comprehensively review the dual role of microglia during the different phases of ischemic stroke, and the possible mechanisms controlling the post-ischemic activity of microglia. In addition, we discuss the dynamic interactions between microglia and other cells, such as neurons, astrocytes, oligodendrocytes, and endothelial cells within the brain parenchyma and the neurovascular unit.

引用

页码：921 / 933

页数：13

共 145 条

[1] Interferon regulatory factor 4/5 signaling impacts on microglial activation after ischemic stroke in mice [J].

Al Mamun, Abdullah ;

Chauhan, Anjali ;

Yu, Haifu ;

Xu, Yan ;

Sharmeen, Romana ;

Liu, Fudong .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2018, 47 (02) :140-149

[2] Post-ischemic brain damage: pathophysiology and role of inflammatory mediators [J].

Amantea, Diana ;

Nappi, Giuseppe ;

Bernardi, Giorgio ;

Bagetta, Giacinto ;

Corasaniti, Maria T. .

FEBS JOURNAL, 2009, 276 (01) :13-26

[3] Induction of Notch signaling by tumor necrosis factor in rheumatoid synovial fibroblasts [J].

Ando, K ;

Kanazawa, S ;

Tetsuka, T ;

Ohta, S ;

Jiang, X ;

Tada, T ;

Kobayashi, M ;

Matsui, N ;

Okamoto, T .

ONCOGENE, 2003, 22 (49) :7796-7803

[4] Gamma secretase-mediated notch signaling worsens brain damage and functional outcome in ischemic stroke [J].

Arumugam, TV ;

Chan, SL ;

Jo, DG ;

Yilmaz, G ;

Tang, SC ;

Cheng, AW ;

Gleichmann, M ;

Okun, E ;

Dixit, VD ;

Chigurupati, S ;

Mughal, MR ;

Ouyang, X ;

Miele, L ;

Magnus, T ;

Poosala, S ;

Granger, DN ;

Mattson, MP .

NATURE MEDICINE, 2006, 12 (06) :621-623

[5] Neuronal replacement from endogenous precursors in the adult brain after stroke [J].

Arvidsson, A ;

Collin, T ;

Kirik, D ;

Kokaia, Z ;

Lindvall, O .

NATURE MEDICINE, 2002, 8 (09) :963-970

[6] Effects of TNF-α and IFN-γ on nitric oxide-induced neurotoxicity in the mouse brain [J].

Blais, V ;

Rivest, S .

JOURNAL OF IMMUNOLOGY, 2004, 172 (11) :7043-7052

[7] Microglia-mediated neurotoxicity: uncovering the molecular mechanisms [J].

Block, Michelle L. ;

Zecca, Luigi ;

Hong, Jau-Shyong .

NATURE REVIEWS NEUROSCIENCE, 2007, 8 (01) :57-69

[8] Toll-like receptor 2 deficiency leads to delayed exacerbation of ischemic injury [J].

Bohacek, Ivan ;

Cordeau, Pierre ;

Lalancette-Hebert, Melanie ;

Gorup, Dunja ;

Weng, Yuan-Cheng ;

Gajovic, Srecko ;

Kriz, Jasna .

JOURNAL OF NEUROINFLAMMATION, 2012, 9

[9] Microglia activated by IL-4 or IFN-γ differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells [J].

Butovsky, O ;

Ziv, Y ;

Schwartz, A ;

Landa, G ;

Talpalar, AE ;

Pluchino, S ;

Martino, G ;

Schwartz, M .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2006, 31 (01) :149-160

[10] Control of microglial neurotoxicity by the fractalkine receptor [J].

Cardona, Astrid E. ;

Pioro, Erik P. ;

Sasse, Margaret E. ;

Kostenko, Volodymyr ;

Cardona, Sandra M. ;

Dijkstra, Ineke M. ;

Huang, DeRen ;

Kidd, Grahame ;

Dombrowski, Stephen ;

Dutta, RanJan ;

Lee, Jar-Chi ;

Cook, Donald N. ;

Jung, Steffen ;

Lira, Sergio A. ;

Littman, Dan R. ;

Ransohoff, Richard M. .

NATURE NEUROSCIENCE, 2006, 9 (07) :917-924

← 1 2 3 4 5 6 7 8 9 10 →