eIF3C as a prognostic marker of colorectal cancer

Eukaryotic translation initiation factor 3C (eIF3C) is a component of the eukaryotic translation initiation factor 3 (eIF3) complexes, which has a crucial role in the translation initiation process. As we know, translational control plays a key role in the complex mechanism of cancer development and progression. Besides, eIF3C downregulation decreases the global protein synthesis and causes a polysome run-off. In vitro and clinical trials were made to prove the relationship of eIF3C and colorectal cancer (CRC). We analyzed the eIF3C expression in a tissue microarray (TMA), which contained 198 colorectal cancer tissues and paired adjacent normal mucosa. The immunohistochemistry was used to assess the relative expression level of eIF3C and its value as a prognostic marker. SPSS was used to analysis the data to figure out the association between eIF3C and CRC. eIF3C was found highly expressed in CRC cells by in vitro experiments and clinical researches, and it can influence tumor proliferation, colony formation and cell cycle. In addition, eIF3C is an independent risk factor for CRC patients both OR and RFS. All in all, high eIF3C expression may contribute to tumor progression and predict poor clinical staging of colorectal cancer.