Synthesis from Undecylenic Acid of Macroheterocycles with Diacylhydrazine and Ester Fragments

被引：0

作者：

Mingaleeva, G. R. ^{[1
]}

Yakovleva, M. P. ^{[1
]}

Ishmuratov, G. Yu. ^{[1
]}

机构：

[1] Russian Acad Sci, Ufa Inst Chem, Ufa Fed Res Ctr, 71 Prosp Oktyabrya, Ufa 450054, Russia

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2019年 / 55卷 / 05期

关键词：

undecylenic acid; ozonolysis; hydroboration-oxidation; 2+1]-condensation; 1+1]-condensation; macroheterocycles; synthesis; PURE MACROHETEROCYCLE;

D O I：

10.1007/s10600-019-02840-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A three-step synthesis of potentially biologically active 30- and 32-membered macroheterocycles with esters and acylhydrazines starting from methyl undecylenate was developed based on [1+1]-condensation of intermediate tetraesters, i.e., bis(10 ' -methoxy-10 ' -oxodecyl)- or bis(11 ' -methoxy-11 ' -oxoundecyl)hexanedioate, with hydrazine hydrate. The structures of the synthesized compounds were confirmed using IR and NMR spectroscopy and mass spectrometry.

引用

页码：895 / 898

页数：4

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