A concise enantioselective synthesis of pyrrolidine sedum alkaloids (R)-(R)-(+), (S)-(S)-(-)-pyrrolsedamine and (S)-(R)-(+)-pyrrolallosedamine by using proline catalysed α-amination reaction

被引：13
|
作者：
Bhosale, Viraj A. [1 ]
Markad, Sachin B. [1 ]
Waghmode, Suresh B. [1 ]
机构：
[1] Savitribai Phule Pune Univ, Dept Chem, Pune 411007, Maharashtra, India
来源：
TETRAHEDRON | 2017年 / 73卷 / 36期
关键词：
alpha-amination; Olefination; Pyrolidine; Sedum alkaloids; HYDROFORMYLATION; DERIVATIVES; SEDAMINE;
D O I：
10.1016/j.tet.2017.07.023
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general approach for the synthesis of pyrolidine member of sedum alkaloids has been developed by employing proline catalysed sequential alpha-amination and Horner-Wadsworth-Emmons (HWE) olefination of an aldehyde as the key steps. This method can be extended for the synthesis of various bioactive natural products containing pyrolidine skeleton. (C) 2017 Published by Elsevier Ltd.
引用
收藏
页码：5344 / 5349
页数：6
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